Gene
slc11a2
- ID
- ZDB-GENE-021115-1
- Name
- solute carrier family 11 member 2
- Symbol
- slc11a2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Exhibits iron ion transmembrane transporter activity. Involved in several processes, including embryonic hemopoiesis; hemoglobin biosynthetic process; and response to copper ion. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Is expressed in several structures, including alar plate midbrain region; digestive system; lens; solid lens vesicle; and ventral mesoderm. Orthologous to human SLC11A2 (solute carrier family 11 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb426 (11 images)
- IMAGE:7138101 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypochromic microcytic anemia | Alliance | Anemia, hypochromic microcytic, with iron overload 1 | 206100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR001046 | NRAMP family |
Domain Details Per Protein
| Protein | Length | NRAMP family |
|---|---|---|
|
UniProtKB:Q1RLY4
|
547 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc11a2-201
(1)
|
Ensembl | 1,663 nt |
Interactions and Pathways
No data available
Plasmids
No data available