Gene

smoc2

ID

ZDB-GENE-021031-5

Name

SPARC related modular calcium binding 2

Symbol

smoc2 Nomenclature History

Previous Names

cb488 (1)
wu:fb75d10
zgc:112171

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in animal organ development and regulation of BMP signaling pathway. Predicted to localize to collagen-containing extracellular matrix. Is expressed in several structures, including digestive system; ectoderm; nervous system; notochord; and optic vesicle. Orthologous to human SMOC2 (SPARC related modular calcium binding 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb488 (24 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smoc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dentin dysplasia	Alliance	Dentin dysplasia, type I, with microdontia and misshapen teeth	125400

Associated With smoc2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR002350	Kazal domain
Domain	IPR019577	SPARC/Testican, calcium-binding domain
Domain	IPR037640	SMOC-2, extracellular calcium-binding domain
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily

Domain Details Per Protein

Protein	Length	EF-Hand 1, calcium-binding site	EF-hand domain pair	Kazal domain	SMOC-2, extracellular calcium-binding domain	SPARC/Testican, calcium-binding domain	Thyroglobulin type-1	Thyroglobulin type-1 superfamily
UniProtKB:A0A8M6Z9N4 InterPro	502

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations