Gene
npm1a
- ID
- ZDB-GENE-021028-1
- Name
- nucleophosmin 1a
- Symbol
- npm1a Nomenclature History
- Previous Names
-
- npm1
- sb:cb487
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have chromatin binding activity and histone binding activity. Involved in hemopoiesis and regulation of apoptotic process. Localizes to nucleolus. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is expressed in several structures, including digestive system; fin bud; hematopoietic cell; nervous system; and neural tube. Orthologous to human NPM1 (nucleophosmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb487 (32 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bolli et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nucleophosmin, C-terminal | Nucleoplasmin core domain | Nucleoplasmin core domain superfamily | Nucleoplasmin family |
|---|---|---|---|---|---|
|
UniProtKB:E7FCU0
|
279 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
npm1a-201
(1)
|
Ensembl | 481 nt | ||
| mRNA |
npm1a-202
(1)
|
Ensembl | 846 nt | ||
| mRNA |
npm1a-204
(1)
|
Ensembl | 1,615 nt | ||
| mRNA |
npm1a-205
(1)
|
Ensembl | 809 nt | ||
| ncRNA |
npm1a-002
(1)
|
Ensembl | 838 nt | ||
| ncRNA |
npm1a-003
(1)
|
Ensembl | 519 nt | ||
| ncRNA |
npm1a-004
(1)
|
Ensembl | 549 nt |
Interactions and Pathways
No data available
Plasmids
No data available