Gene
npm1a
- ID
- ZDB-GENE-021028-1
- Name
- nucleophosmin 1a
- Symbol
- npm1a Nomenclature History
- Previous Names
-
- npm1
- sb:cb487
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Acts upstream of or within hemopoiesis and regulation of apoptotic process. Located in nucleolus. Is expressed in several structures, including digestive system; fin bud; hematopoietic cell; nervous system; and neural tube. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb487 (32 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Bolli et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011819Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017452Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017453Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8446 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa8620 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-npm1a | N/A | Bolli et al., 2010 |
| MO2-npm1a | N/A | Bolli et al., 2010 |
| MO3-npm1a | N/A | (2) |
| TALEN1-npm1a | Ma et al., 2013 | |
| TALEN2-npm1a | Ma et al., 2013 |
1 - 5 of 5
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleophosmin, C-terminal | Nucleoplasmin core domain | Nucleoplasmin core domain superfamily | Nucleoplasmin family |
|---|---|---|---|---|---|---|
| UniProtKB:E7FCU0 | InterPro | 279 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-4C2 | ZFIN Curated Data | |
| Encodes | EST | cb487 | ZFIN Curated Data | |
| Encodes | EST | fb38d12 | Langenau et al., 2002 | |
| Encodes | cDNA | MGC:64077 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174058 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191814 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199428 (1) | 1598 nt | ||
| Genomic | GenBank:BX005027 (1) | 241472 nt | ||
| Polypeptide | UniProtKB:E7FCU0 (1) | 279 aa |
- Xu, B., Tang, X., Jin, M., Zhang, H., Du, L., Yu, S., He, J. (2020) Unifying Developmental Programs for Embryonic and Post-Embryonic Neurogenesis in the Zebrafish Retina. Development (Cambridge, England). 147(12):
- Cheung, C.T., Pasquier, J., Bouleau, A., Nguyen, T., Chesnel, F., Guiguen, Y., Bobe, J. (2018) Double maternal-effect: duplicated nucleoplasmin 2 genes, npm2a and npm2b, with essential but distinct functions are shared by fish and tetrapods. BMC Evolutionary Biology. 18:167
- Ando, K., Parsons, M.J., Shah, R.B., Charendoff, C.I., Paris, S.L., Liu, P.H., Fassio, S.R., Rohrman, B.A., Thompson, R., Oberst, A., Sidi, S., Bouchier-Hayes, L. (2017) NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus. The Journal of cell biology. 216:1795-1810
- Chakraborty, A., Uechi, T., Nakajima, Y., Gazda, H.T., O'Donohue, M.F., Gleizes, P.E., Kenmochi, N. (2017) Cross talk between TP53 and c-Myc in the pathophysiology of Diamond-Blackfan anemia: Evidence from RPL11-deficient in vivo and in vitro models. Biochemical and Biophysical Research Communications. 495(2):1839-1845
- Liu, Q., Klingler, R.H., Wimpee, B., Dellinger, M., King-Heiden, T., Grzybowski, J., Gerstenberger, S.L., Weber, D.N., Caravan, M.J. (2016) Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 65:272-282
- Ma, A.C., Lee, H.B., Clark, K.J., and Ekker, S.C. (2013) High Efficiency In Vivo Genome Engineering with a Simplified 15-RVD GoldyTALEN Design. PLoS One. 8(5):e65259
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gutierrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E., Mansour, M., Dahlberg, S.E., Neuberg, D.S., Hertog, J.D., Prochownik, E.V., Testa, J.R., Harris, M., Kanki, J.P., and Look, A.T. (2011) Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 208(8):1595-603
- Mirbahai, L., Williams, T.D., Zhan, H., Gong, Z., and Chipman, J.K. (2011) Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. BMC Genomics. 12:3
- Bolli, N., Payne, E.M., Grabher, C., Lee, J.S., Johnston, A.B., Falini, B., Kanki, J.P., and Look, A.T. (2010) Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish. Blood. 115(16):3329-3340
1 - 10 of 16
Show