Gene
tlx1
- ID
- ZDB-GENE-021021-2
- Name
- T cell leukemia homeobox 1
- Symbol
- tlx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within regulation of immune response and spleen development. Predicted to be active in nucleus. Is expressed in cerebellum; gut; hindbrain; pharyngeal arch; and spleen. Human ortholog(s) of this gene implicated in adult T-cell leukemia/lymphoma. Orthologous to human TLX1 (T cell leukemia homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cq201 | Allele with one delins | Unknown | Frameshift | CRISPR | |
| cq202 | Allele with one insertion | Unknown | Frameshift | CRISPR | |
| ihb184 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb185 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| sa11549 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22315 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zf3887 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zf3888 | Allele with one point mutation | Exon 2 | Unknown | CRISPR | |
| zf3889 | Allele with one point mutation | Exon 2 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tlx1 | (2) | |
| CRISPR2-tlx1 | (2) | |
| CRISPR3-tlx1 | (3) | |
| CRISPR4-tlx1 | Liu et al., 2022 | |
| CRISPR5-tlx1 | Liu et al., 2022 | |
| MO1-tlx1 | N/A | Sundaramoorthi et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa | T-cell leukemia homeobox protein 1/2/3 |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JI13 | InterPro | 301 | |||||
| UniProtKB:A0AB32U4N7 | InterPro | 289 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-103O12 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-46P4 | ||
| Contained in | PAC | BUSM1-265N4 | ||
| Encodes | cDNA | MGC:193594 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193596 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_170765 (1) | 2223 nt | ||
| Genomic | GenBank:BX950184 (2) | 150475 nt | ||
| Polypeptide | UniProtKB:Q8JI13 (1) | 301 aa |
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Liu, Y., Qu, M., Jiang, H., Schneider, R., Qin, G., Luo, W., Yu, H., Zhang, B., Wang, X., Zhang, Y., Zhang, H., Zhang, Z., Wu, Y., Zhang, Y., Yin, J., Zhang, S., Venkatesh, B., Roth, O., Meyer, A., Lin, Q. (2022) Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia. Nature communications. 13:76107610
- Lin, Z., Luo, M., Zhou, B., Liu, Y., Sun, H. (2021) CFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish. Immunology Letters. 234:47-53
- Xie, L., Chen, Z., Guo, H., Tao, Y., Miao, X., Wu, R., Li, Y. (2021) Congenital Asplenia Interrupts Immune Homeostasis and Leads to Excessive Systemic Inflammation in Zebrafish. Frontiers in cellular and infection microbiology. 11:668859
- Loontiens, S., Vanhauwaert, S., Depestel, L., Dewyn, G., Van Loocke, W., Moore, F.E., Garcia, E.G., Batchelor, L., Borga, C., Squiban, B., Malone-Perez, M., Volders, P.J., Olexiouk, V., Van Vlierberghe, P., Langenau, D.M., Frazer, J.K., Durinck, K., Speleman, F. (2020) A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models. Leukemia. 34(12):3398-3403
- Xie, L., Tao, Y., Wu, R., Ye, Q., Xu, H., Li, Y. (2019) Congenital asplenia due to a tlx1 mutation reduces resistance to Aeromonas hydrophila infection in zebrafish. Fish & shellfish immunology. 95:538-545
- Lobbardi, R., Pinder, J., Martinez-Pastor, B., Theodorou, M., Blackburn, J.S., Abraham, B.J., Namiki, Y., Mansour, M., Abdelfattah, N.S., Molodtsov, A., Alexe, G., Toiber, D., de Waard, M., Jain, E., Boukhali, M., Lion, M., Bhere, D., Shah, K., Gutierrez, A., Stegmaier, K., Silverman, L.B., Sadreyev, R.I., Asara, J.M., Oettinger, M.A., Haas, W., Look, A.T., Young, R.A., Mostoslavsky, R., Dellaire, G., Langenau, D.M. (2017) TOX regulates growth, DNA repair, and genomic instability in T-cell Acute Lymphoblastic Leukemia. Cancer discovery. 7(11):1336-1353
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Blackburn, J.S., Liu, S., Raiser, D.M., Martinez, S.A., Feng, H., Meeker, N.D., Gentry, J., Neuberg, D., Look, A.T., Ramaswamy, S., Bernards, A., Trede, N.S., and Langenau, D.M. (2012) Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 26(9):2069-2078
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