Gene

sec61a1l

ID
ZDB-GENE-021016-2
Name
SEC61 translocon subunit alpha 1, like
Symbol
sec61a1l Nomenclature History
Previous Names
  • cb413 (1)
  • sec61al2
  • sec61b
  • wu:fb36f05
  • wu:fb36f12
  • wu:fb37d04
  • wu:fi26f11
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Involved in pronephros development. Predicted to localize to Sec61 translocon complex. Is expressed in several structures, including EVL; anterior axial hypoblast; axis; ectoderm; and mesoderm. Human ortholog(s) of this gene implicated in familial juvenile hyperuricemic nephropathy. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Bolar et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sec61a1l Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Tubulointerstitial kidney disease, autosomal dominant, 5 617056
Associated With sec61a1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR030659 SecY conserved site
Domain IPR019561 Translocon Sec61/SecY, plug domain
Family IPR002208 SecY/SEC61-alpha family
Homologous_superfamily IPR023201 SecY domain superfamily
Domain Details Per Protein
Protein Length SecY conserved site SecY domain superfamily SecY/SEC61-alpha family Translocon Sec61/SecY, plug domain
UniProtKB:Q90YL4 476
UniProtKB:A0A0J9YIG5 476
UniProtKB:B2GS26 476
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations