Gene
adra2a
- ID
- ZDB-GENE-021010-1
- Name
- adrenoceptor alpha 2A
- Symbol
- adra2a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables alpha2-adrenergic receptor activity. Involved in adenylate cyclase-inhibiting adrenergic receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including gut; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; familial partial lipodystrophy; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu88 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa24199 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39378 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43873 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45776 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 4 of 4
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Lipodystrophy, familial partial, type 8 | 620679 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Adrenoceptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
| UniProtKB:Q1L8Y8 | InterPro | 388 | |||
| UniProtKB:Q90WY4 | InterPro | 388 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adra2a-201
(1)
|
Ensembl | 1,432 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-128N21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-197I12 | ZFIN Curated Data | |
| Encodes | EST | eu88 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:136703 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207637 (1) | 2645 nt | ||
| Genomic | GenBank:CR450802 (1) | 186908 nt | ||
| Polypeptide | UniProtKB:Q1L8Y8 (1) | 388 aa |
- Rodrigues, P., Cunha, V., Ferreira, M., Armanda Reis-Henriques, M., Oliva-Teles, L., Guimarães, L., Paulo Carvalho, A. (2022) Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine. Water. 14(3):417
- Kumar, N., Zhao, H.N., Awoyemi, O., Kolodziej, E.P., Crago, J. (2021) Toxicity Testing of Effluent-Dominated Stream Using Predictive Molecular-Level Toxicity Signatures Based on High-Resolution Mass Spectrometry: A Case Study of the Lubbock Canyon Lake System. Environmental science & technology. 55(5):3070-3080
- Rodrigues, P., Cunha, V., Oliva-Teles, L., Ferreira, M., Guimarães, L. (2020) Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. Journal of hazardous materials. 400:123171
- Cunha, V., Rodrigues, P., Santos, M.M., Moradas-Ferreira, P., Ferreira, M. (2017) Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos. Chemosphere. 191:954-961
- Mei, Y., Yin, N., Jin, X., He, J., and Yin Z. (2013) The regulatory role of the adrenergic agonists phenylephrine and isoproterenol on fetal hemoglobin expression and erythroid differentiation. Endocrinology. 154(12):4640-9
- Klee, E.W., Schneider, H., Clark, K.J., Cousin, M.A., Ebbert, J.O., Hooten, W.M., Karpyak, V.M., Warner, D.O., and Ekker, S.C. (2012) Zebrafish: a model for the study of addiction genetics. Human genetics. 131(6):977-1008
- Ampatzis, K., Kentouri, M., and Dermon, C.R. (2008) Neuronal and glial localization of alpha(2A)-adrenoceptors in the adult zebrafish (Danio rerio) brain. The Journal of comparative neurology. 508(1):72-93
- Yokogawa, T., Marin, W., Faraco, J., Pézeron, G., Appelbaum, L., Zhang, J., Rosa, F., Mourrain, P., and Mignot, E. (2007) Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants. PLoS Biology. 5(10):2379-2397
- Bylund, D.B. (2005) Alpha-2 adrenoceptor subtypes: are more better?. British journal of pharmacology. 144(2):159-160
- Ruuskanen, J.O., Laurila, J., Xhaard, H., Rantanen, V.V., Vuoriluoto, K., Wurster, S., Marjamaki, A., Vainio, M., Johnson, M.S., and Scheinin, M. (2005) Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha(2)-adrenoceptors. British journal of pharmacology. 144(2):165-177
1 - 10 of 13
Show