Gene
mapk14b
- ID
- ZDB-GENE-021007-1
- Name
- mitogen-activated protein kinase 14b
- Symbol
- mapk14b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase activity. Predicted to be involved in several processes, including p38MAPK cascade; positive regulation of cell differentiation; and positive regulation of myoblast fusion. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from Krens et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb723 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
| ihb730 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
| la017805Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la017807Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35004 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mapk14b | Zebrafish Nomenclature Committee |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR003527 | Mitogen-activated protein (MAP) kinase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Family | IPR008352 | Mitogen-activated protein (MAP) kinase p38-like |
| Family | IPR050117 | Mitogen-activated protein kinase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Mitogen-activated protein kinase | Mitogen-activated protein (MAP) kinase, conserved site | Mitogen-activated protein (MAP) kinase p38-like | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RAA2 | InterPro | 361 | ||||||
| UniProtKB:Q9DGE1 | InterPro | 348 | ||||||
| UniProtKB:F1QQ40 | InterPro | 361 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mapk14b-201
(1)
|
Ensembl | 4,174 nt | ||
| mRNA |
mapk14b-202
(1)
|
Ensembl | 1,838 nt | ||
| mRNA |
mapk14b-203
(1)
|
Ensembl | 1,531 nt | ||
| ncRNA |
mapk14b-004
(1)
|
Ensembl | 773 nt | ||
| ncRNA |
mapk14b-005
(1)
|
Ensembl | 806 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160O17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:65760 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77585 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001313759 (1) | 4194 nt | ||
| Genomic | GenBank:CR318593 (1) | 166837 nt | ||
| Polypeptide | UniProtKB:F1QQ40 (1) | 361 aa |
- Zhou, C., Chen, J., Liu, K., Maharajan, K., Zhang, Y., Hou, L., Li, J., Mi, M., Xia, Q. (2023) Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 160:114315114315
- Sojan, J.M., Gundappa, M.K., Carletti, A., Gaspar, V., Gavaia, P., Maradonna, F., Carnevali, O. (2022) Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Frontiers in nutrition. 9:868805
- Wohlfart, D.P., Lou, B., Middel, C.S., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Hell, R., Hammes, H.P., Szendrödi, J., Nawroth, P.P., Kroll, J. (2022) Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redox Biology. 50:102249
- Bereketoglu, C., Pradhan, A. (2019) Comparative transcriptional analysis of methylparaben and propylparaben in zebrafish. The Science of the total environment. 671:129-139
- Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. The Science of the total environment. 702:134969
- Wu, Q., Yan, W., Liu, C., Hung, T.C., Li, G. (2019) Co-exposure with titanium dioxide nanoparticles exacerbates MCLR-induced brain injury in zebrafish. The Science of the total environment. 693:133540
- Chen, S., Yu, M., Chu, X., Li, W., Yin, X., Chen, L. (2017) Cold-induced retrotransposition of fish LINEs. Journal of genetics and genomics = Yi chuan xue bao. 44(8):385-394
- Yin, J., Wang, A.P., Li, W.F., Shi, R., Jin, H.T., Wei, J.F. (2017) Sensitive biomarkers identification for differentiating Cd and Pb induced toxicity on zebrafish embryos. Environmental Toxicology and Pharmacology. 56:340-349
- Zhao, F., Shi, Y., Huang, Y., Zhan, Y., Zhou, L., Li, Y., Wan, Y., Li, H., Huang, H., Ruan, H., Luo, L., Li, L. (2017) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish. Leukemia. 32(1):149-158
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
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