Gene
dnah9
- ID
- ZDB-GENE-020925-1
- Name
- dynein, axonemal, heavy chain 9
- Symbol
- dnah9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Acts upstream of or within determination of heart left/right asymmetry and epithelial cilium movement involved in determination of left/right asymmetry. Located in extracellular region. Is expressed in several structures, including mesoderm; nervous system; neural tube; pleuroperitoneal region; and tail bud. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 40. Orthologous to human DNAH9 (dynein axonemal heavy chain 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63607 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Chen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 40 | Alliance | Ciliary dyskinesia, primary, 40 | 618300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004273 | Dynein heavy chain region D6 P-loop domain |
| Domain | IPR013594 | Dynein heavy chain, tail |
| Domain | IPR013602 | Dynein heavy chain, linker |
| Domain | IPR024317 | Dynein heavy chain, AAA module D4 |
| Domain | IPR024743 | Dynein heavy chain, coiled coil stalk |
| Domain | IPR035699 | Dynein heavy chain, hydrolytic ATP-binding dynein motor region |
| Domain | IPR035706 | Dynein heavy chain, ATP-binding dynein motor region |
| Domain | IPR041228 | Dynein heavy chain, C-terminal domain |
| Domain | IPR041466 | Dynein heavy chain, AAA 5 extension domain |
| Domain | IPR041589 | Dynein heavy chain 3, AAA+ lid domain |
| Domain | IPR041658 | Dynein heavy chain AAA lid domain |
| Family | IPR026983 | Dynein heavy chain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR042219 | Dynein heavy chain AAA lid domain superfamily |
| Homologous_superfamily | IPR042222 | Dynein heavy chain, domain 2, N-terminal |
| Homologous_superfamily | IPR042228 | Dynein heavy chain, linker, subdomain 3 |
| Homologous_superfamily | IPR043157 | Dynein heavy chain, AAA1 domain, small subdomain |
| Homologous_superfamily | IPR043160 | Dynein heavy chain, C-terminal domain, barrel region |
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynein heavy chain | Dynein heavy chain 3, AAA+ lid domain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | Dynein heavy chain, tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13A7H0 | InterPro | 4464 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available