Gene

atp2a1

ID

ZDB-GENE-020905-1

Name

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

Symbol

atp2a1 Nomenclature History

Previous Names

acc
accordion
cb279 (1)
serca1 (1)
serca (1)
wu:cegs655
wu:fb17h11
wu:fb19b10
zgc:92110

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have several functions, including ATP binding activity; calcium ion binding activity; and ion transmembrane transporter activity, phosphorylative mechanism. Involved in several processes, including cellular calcium ion homeostasis; negative regulation of muscle contraction; and relaxation of skeletal muscle. Predicted to localize to several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; sarcomere; and sarcoplasmic reticulum membrane. Used to study Brody myopathy. Human ortholog(s) of this gene implicated in Brody myopathy. Is expressed in several structures, including eye; gill; mesoderm; musculature system; and pectoral fin. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

41 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb279 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atp2a1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Brody myopathy	Alliance	Brody myopathy	601003

Associated With atp2a1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Brody myopathy	atp2a1^mi25i/mi25i	standard conditions	Hirata et al., 2004
Brody myopathy	atp2a1^{mi289a/mi289a}	standard conditions	Hirata et al., 2004
Brody myopathy	atp2a1^tq206/tq206	standard conditions	Hirata et al., 2004

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004014	Cation-transporting P-type ATPase, N-terminal
Domain	IPR006068	Cation-transporting P-type ATPase, C-terminal
Domain	IPR044492	P-type ATPase, haloacid dehalogenase domain
Family	IPR001757	P-type ATPase
Family	IPR005782	P-type ATPase, subfamily IIA, SERCA-type
Homologous_superfamily	IPR008250	P-type ATPase, A domain superfamily
Homologous_superfamily	IPR023214	HAD superfamily
Homologous_superfamily	IPR023298	P-type ATPase, transmembrane domain superfamily
Homologous_superfamily	IPR023299	P-type ATPase, cytoplasmic domain N
Homologous_superfamily	IPR036412	HAD-like superfamily
PTM	IPR018303	P-type ATPase, phosphorylation site

Domain Details Per Protein

Protein	Length	Cation-transporting P-type ATPase, C-terminal	Cation-transporting P-type ATPase, N-terminal	HAD-like superfamily	HAD superfamily	P-type ATPase	P-type ATPase, A domain superfamily	P-type ATPase, cytoplasmic domain N	P-type ATPase, haloacid dehalogenase domain	P-type ATPase, phosphorylation site	P-type ATPase, subfamily IIA, SERCA-type	P-type ATPase, transmembrane domain superfamily
UniProtKB:Q642Z0 InterPro	994

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	atp2a1-201 (1) Ensembl	Ensembl	3,390 nt	Select Tool
mRNA	atp2a1-202 (1) Ensembl	Ensembl	3,311 nt	Select Tool
mRNA	atp2a1-203 (1) Ensembl	Ensembl	1,049 nt	Select Tool
mRNA	atp2a1-205 (1) Ensembl	Ensembl	416 nt	Select Tool
mRNA	atp2a1-206 (1) Ensembl	Ensembl	502 nt	Select Tool
mRNA	atp2a1-208 (1) Ensembl	Ensembl	3,041 nt	Select Tool ZFIN BLAST
ncRNA	atp2a1-003 (1) Ensembl	Ensembl	520 nt	Select Tool
ncRNA	atp2a1-004 (1) Ensembl	Ensembl	348 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations