Gene
atp2a1
- ID
- ZDB-GENE-020905-1
- Name
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
- Symbol
- atp2a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have several functions, including ATP binding activity; calcium ion binding activity; and ion transmembrane transporter activity, phosphorylative mechanism. Involved in several processes, including cellular calcium ion homeostasis; negative regulation of muscle contraction; and relaxation of skeletal muscle. Predicted to localize to several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; sarcomere; and sarcoplasmic reticulum membrane. Used to study Brody myopathy. Human ortholog(s) of this gene implicated in Brody myopathy. Is expressed in several structures, including eye; gill; mesoderm; musculature system; and pectoral fin. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb279 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Brody myopathy | Alliance | Brody myopathy | 601003 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Family | IPR001757 | P-type ATPase |
| Family | IPR005782 | P-type ATPase, subfamily IIA, SERCA-type |
| Homologous_superfamily | IPR008250 | P-type ATPase, A domain superfamily |
| Homologous_superfamily | IPR023214 | HAD superfamily |
| Homologous_superfamily | IPR023298 | P-type ATPase, transmembrane domain superfamily |
| Homologous_superfamily | IPR023299 | P-type ATPase, cytoplasmic domain N |
| Homologous_superfamily | IPR036412 | HAD-like superfamily |
| PTM | IPR018303 | P-type ATPase, phosphorylation site |
Domain Details Per Protein
| Protein | Length | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase, subfamily IIA, SERCA-type | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q642Z0
|
994 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp2a1-201
(1)
|
Ensembl | 3,390 nt | ||
| mRNA |
atp2a1-202
(1)
|
Ensembl | 3,311 nt | ||
| mRNA |
atp2a1-203
(1)
|
Ensembl | 1,049 nt | ||
| mRNA |
atp2a1-205
(1)
|
Ensembl | 416 nt | ||
| mRNA |
atp2a1-206
(1)
|
Ensembl | 502 nt | ||
| mRNA |
atp2a1-208
(1)
|
Ensembl | 3,041 nt | ||
| ncRNA |
atp2a1-003
(1)
|
Ensembl | 520 nt | ||
| ncRNA |
atp2a1-004
(1)
|
Ensembl | 348 nt |
Interactions and Pathways
No data available
Plasmids