Gene

atp2a1

ID
ZDB-GENE-020905-1
Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
Symbol
atp2a1 Nomenclature History
Previous Names
  • acc
  • accordion
  • cb279 (1)
  • serca1 (1)
  • serca (1)
  • wu:cegs655
  • wu:fb17h11
  • wu:fb19b10
  • zgc:92110
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have several functions, including ATP binding activity; calcium ion binding activity; and ion transmembrane transporter activity, phosphorylative mechanism. Involved in several processes, including cellular calcium ion homeostasis; negative regulation of muscle contraction; and relaxation of skeletal muscle. Predicted to localize to several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; sarcomere; and sarcoplasmic reticulum membrane. Is expressed in several structures, including eye; gill; mesoderm; musculature system; and pectoral fin. Used to study Brody myopathy. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1).
Genome Resources
Note
None
Expression
All Expression Data
40 figures from 12 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atp2a1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Brody myopathy Alliance Brody myopathy 601003
Associated With atp2a1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004014 Cation-transporting P-type ATPase, N-terminal
Domain IPR006068 Cation-transporting P-type ATPase, C-terminal
Family IPR001757 P-type ATPase
Family IPR005782 P-type ATPase, subfamily IIA, SERCA-type
Homologous_superfamily IPR008250 P-type ATPase, A domain superfamily
Homologous_superfamily IPR023214 HAD superfamily
Homologous_superfamily IPR023298 P-type ATPase, transmembrane domain superfamily
Homologous_superfamily IPR023299 P-type ATPase, cytoplasmic domain N
Homologous_superfamily IPR036412 HAD-like superfamily
PTM IPR018303 P-type ATPase, phosphorylation site
Domain Details Per Protein
Protein Length Cation-transporting P-type ATPase, C-terminal Cation-transporting P-type ATPase, N-terminal HAD-like superfamily HAD superfamily P-type ATPase P-type ATPase, A domain superfamily P-type ATPase, cytoplasmic domain N P-type ATPase, phosphorylation site P-type ATPase, subfamily IIA, SERCA-type P-type ATPase, transmembrane domain superfamily
UniProtKB:E9QF60 97
UniProtKB:E9QCD9 39
UniProtKB:Q5U3A4 1005
UniProtKB:E9QGF0 102
UniProtKB:Q642Z0 994
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations