Gene
sim1a
- ID
- ZDB-GENE-020829-1
- Name
- SIM bHLH transcription factor 1a
- Symbol
- sim1a Nomenclature History
- Previous Names
-
- sim1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within nervous system development and proximal tubule development. Predicted to be located in nucleus. Is expressed in several structures, including basal plate midbrain region; central nervous system; corpuscles of Stannius; intermediate mesoderm; and pronephros. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 40 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR010578 | Single-minded, C-terminal |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013655 | PAS fold-3 |
| Domain | IPR013767 | PAS fold |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily | PAS fold | PAS fold-3 | Single-minded, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QMF7 | InterPro | 745 | ||||||||
| UniProtKB:Q98SJ5 | InterPro | 745 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available