Gene
sim1a
- ID
- ZDB-GENE-020829-1
- Name
- SIM bHLH transcription factor 1a
- Symbol
- sim1a Nomenclature History
- Previous Names
-
- sim1
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in nervous system development and proximal tubule development. Predicted to localize to nucleus. Is expressed in several structures, including basal plate midbrain region; central nervous system; corpuscles of Stannius; intermediate mesoderm; and pronephros. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000014 | PAS domain |
Domain | IPR010578 | Single-minded, C-terminal |
Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
Domain | IPR013655 | PAS fold-3 |
Domain | IPR013767 | PAS fold |
Homologous_superfamily | IPR035965 | PAS domain superfamily |
Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | PAC motif | PAS domain | PAS domain superfamily | PAS fold | PAS fold-3 | Single-minded, C-terminal |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q98SJ5
|
745 | ||||||||
UniProtKB:F1QMF7
|
745 |
Interactions and Pathways
No data available
Plasmids
No data available