Gene

mst1

ID

ZDB-GENE-020806-3

Name

macrophage stimulating 1

Symbol

mst1 Nomenclature History

Previous Names

msp (1)
cb981 (1)
hgfl1 (1)
macrophage-stimulating protein (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have serine-type endopeptidase activity. Involved in bone mineralization and inflammatory response. Used to study inflammatory bowel disease. Is expressed in digestive system; margin; and yolk syncytial layer. Orthologous to several human genes including MST1 (macrophage stimulating 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb981 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mst1 Human Ortholog

No data available

Associated With mst1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
inflammatory bowel disease	mst1^{t34230/t34230}	standard conditions	Witte et al., 2014

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018056	Kringle, conserved site
Domain	IPR000001	Kringle
Domain	IPR001254	Serine proteases, trypsin domain
Domain	IPR003609	PAN/Apple domain
Family	IPR001314	Peptidase S1A, chymotrypsin family
Family	IPR024174	Hepatocyte growth factor/Macrophage stimulatory protein
Family	IPR050759	Serine proteases and regulators with kringle domains
Homologous_superfamily	IPR009003	Peptidase S1, PA clan
Homologous_superfamily	IPR013806	Kringle-like fold
Homologous_superfamily	IPR038178	Kringle superfamily
Homologous_superfamily	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold