Gene
thbs1b
- ID
- ZDB-GENE-020708-1
- Name
- thrombospondin 1b
- Symbol
- thbs1b Nomenclature History
- Previous Names
-
- thbs1
- Tsp-1 (1)
- si:dkey-11e23.1
- wu:fc48c03
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity; extracellular matrix binding activity; and heparin binding activity. Predicted to be involved in negative regulation of angiogenesis. Predicted to localize to collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Is expressed in several structures, including axial vasculature; head mesenchyme; nervous system; pectoral fin; and somite. Orthologous to human THBS1 (thrombospondin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157705 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001007 | VWFC domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR008859 | Thrombospondin, C-terminal |
| Domain | IPR048287 | Thrombospondin-like, N-terminal domain |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR028974 | TSP type-3 repeat |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| Repeat | IPR003367 | Thrombospondin, type 3-like repeat |
| Repeat | IPR017897 | Thrombospondin, type 3 repeat |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding domain | EGF-like domain | Thrombospondin, C-terminal | Thrombospondin-like, N-terminal domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | Thrombospondin, type 3-like repeat | Thrombospondin, type 3 repeat | TSP type-3 repeat | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QEE7
|
1170 | |||||||||||
|
UniProtKB:F1QL35
|
1171 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
thbs1b-201
(1)
|
Ensembl | 7,291 nt | ||
| mRNA |
thbs1b-202
(1)
|
Ensembl | 5,303 nt | ||
| mRNA |
thbs1b-204
(1)
|
Ensembl | 7,394 nt | ||
| ncRNA |
thbs1b-002
(1)
|
Ensembl | 574 nt |
Interactions and Pathways
No data available
Plasmids
No data available