Gene

ptk2bb

ID

ZDB-GENE-020507-1

Name

protein tyrosine kinase 2 beta, b

Symbol

ptk2bb Nomenclature History

Previous Names

ptk2b (2)
ptk2bl (1)
im:6900512

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in epidermal growth factor receptor signaling pathway; positive regulation of cell migration; and regulation of cell adhesion. Predicted to act upstream of or within protein phosphorylation and signal complex assembly. Predicted to be located in several cellular components, including anchoring junction; cell projection; and cytoskeleton. Predicted to be active in focal adhesion and plasma membrane. Human ortholog(s) of this gene implicated in breast cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6900512 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptk2bb Human Ortholog

No data available

Associated With ptk2bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000299	FERM domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR005189	Focal adhesion kinase, targeting (FAT) domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR041390	Focal adhesion kinase, N-terminal
Domain	IPR041784	FAK1/PYK2, FERM domain C-lobe
Domain	IPR049385	FAK1-like, FERM domain C-lobe
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR014352	FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain
Homologous_superfamily	IPR036137	Focal adhesion kinase, targeting (FAT) domain superfamily

Domain Details Per Protein

Protein	Length	Band 4.1 domain	FAK1-like, FERM domain C-lobe	FAK1/PYK2, FERM domain C-lobe	FERM/acyl-CoA-binding protein superfamily	FERM central domain	FERM domain	FERM superfamily, second domain	Focal adhesion kinase, N-terminal	Focal adhesion kinase, targeting (FAT) domain	Focal adhesion kinase, targeting (FAT) domain superfamily	PH-like domain superfamily	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Ubiquitin-like domain superfamily
UniProtKB:Q7T2P8 InterPro	1004

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	ptk2bb-202 (1) Ensembl	Ensembl	500 nt	Select Tool ZFIN BLAST
mRNA	ptk2bb-201 (1) Ensembl	Ensembl	3,790 nt	Select Tool ZFIN BLAST
mRNA	ptk2bb-203 (1) Ensembl	Ensembl	3,709 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations