Gene
igf1ra
- ID
- ZDB-GENE-020503-1
- Name
- insulin-like growth factor 1a receptor
- Symbol
- igf1ra Nomenclature History
- Previous Names
-
- IGF-IRa (1)
- sb:eu1090
- wu:fi20b10
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and insulin-like growth factor binding activity. Acts upstream of or within several processes, including embryonic organ development; fin regeneration; and insulin-like growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including digestive system; eye; gill; musculature system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1090 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Schlueter et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Insulin-like growth factor I, resistance to | 270450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Family | IPR016246 | Tyrosine-protein kinase, insulin-like receptor |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, insulin-like receptor | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UZS2
|
1405 | |||||||||||||||||
|
UniProtKB:A0A8M6YTF7
|
1404 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igf1ra-201
(1)
|
Ensembl | 6,276 nt | ||
| mRNA |
igf1ra-203
(1)
|
Ensembl | 4,302 nt | ||
| ncRNA |
igf1ra-002
(1)
|
Ensembl | 578 nt |
Interactions and Pathways
Plasmids
No data available