ZFIN ID: ZDB-GENE-020419-40
Gene Name: aurora kinase B
Gene Symbol: aurkb    Nomenclature History

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Previous Names: aurB (1), cei, cellular island, CHUNP6896, fa09g06, fd02h12, stka, wu:fa09g06, wu:fd02h12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have histone serine kinase activity. Involved in chromosome segregation; cytoskeleton-dependent cytokinesis; and microtubule cytoskeleton organization. Predicted to localize to condensed nuclear chromosome, centromeric region; microtubule cytoskeleton; and midbody. Is expressed in several structures, including blastomere; midbrain hindbrain boundary; nervous system; and proliferative region. Human ortholog(s) of this gene implicated in spermatogenic failure 5. Orthologous to human AURKB (aurora kinase B) and AURKC (aurora kinase C).
Genome Resources: Alliance (1),  Gene:791894 (1),  Ensembl(GRCz11):ENSDARG00000037640 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi1045Tg Transgenic Insertion Exon 5 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi3986Tg Transgenic Insertion Intron 1 Unknown DNA
    la019023Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p63cd Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-aurkb N/A 1
    MO2-aurkb N/A 1
    DISEASE ASSOCIATED WITH aurkb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH aurkb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chromosome segregation (more)
    Cellular Component midbody (more)
    Molecular Function histone serine kinase activity (more)
    GO Terms (all 36)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aurkb-201 (1)    Ensembl 1235
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-aurkb polyclonal Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aurkb No data available
    MARKER RELATIONSHIPS
    aurkb Contained in: [Fosmid] CH1073-380M10 (1)
    aurkb Encodes: [BAC END] zk4g12
    [EST] fa09g06, fd02h12
    [cDNA] MGC:85918 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212566 (1) 1240 nt
    Genomic GenBank:FP243378 (1) 44719 nt
    Select Tool
    Polypeptide UniProtKB:F1RDC1 (1) 320 aa
    Sequence Information (all 19)
    ORTHOLOGY for aurkb ( Chr: 14 )
    CITATIONS (49)