ZFIN is now using GRCz12tu for Genomic Data
Gene
stil
- ID
- ZDB-GENE-020419-39
- Name
- STIL centriolar assembly protein
- Symbol
- stil Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within several processes, including neuron cellular homeostasis; smoothened signaling pathway; and spindle organization. Predicted to be located in centriole. Predicted to be part of procentriole replication complex. Predicted to be active in microtubule organizing center. Is expressed in several structures, including gut; heart; nervous system; optic cup; and pronephros. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 7. Orthologous to human STIL (STIL centriolar assembly protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary autosomal recessive microcephaly 7 | Alliance | Microcephaly 7, primary, autosomal recessive | 612703 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| microcephaly | WT + MO4-stil | standard conditions | Novorol et al., 2013 |
| microcephaly | stilhi1262Tg/hi1262Tg | standard conditions | Novorol et al., 2013 |
| microcephaly | stilcz65/cz65 | standard conditions | Novorol et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026123 | SCL-interrupting locus protein |
Domain Details Per Protein
| Protein | Additional Resources | Length | SCL-interrupting locus protein |
|---|---|---|---|
| UniProtKB:A0A8M6Z3C1 | InterPro | 1016 | |
| UniProtKB:Q8JGS1 | InterPro PDB | 1263 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers