ZFIN ID: ZDB-GENE-020419-39
Gene Name: STIL centriolar assembly protein
Gene Symbol: stil    Nomenclature History

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Previous Names: cassiopeia (1), chunp6907, csp, nbb, sill (1), TAL1 (SCL) interrupting locus like, zgc:110502 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Involved in several processes, including body morphogenesis; smoothened signaling pathway; and spindle organization. Predicted to localize to the centriole and centrosome. Used to study microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 7. Is expressed in several structures, including gut; heart; nervous system; optic cup; and pronephros. Orthologous to human STIL (STIL centriolar assembly protein).
Genome Resources: Alliance (1),  Gene:192317 (1),  Ensembl(GRCz11):ENSDARG00000024904 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cz65 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • cz299 Point Mutation Unknown Premature Stop ENU
    da15 Point Mutation Donor Splice Site Splice Site ENU
    hi1262Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14967 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24122 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29746 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-stil N/A 1
    MO2-stil N/A 1
    MO3-stil N/A 1
    MO4-stil N/A 1
    DISEASE ASSOCIATED WITH stil HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary autosomal recessive microcephaly 7 Alliance Microcephaly 7, primary, autosomal recessive 612703
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process smoothened signaling pathway (more)
    Cellular Component centriole (more)
    Molecular Function protein binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR026123 SCL-interrupting locus protein
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA stil-201 (1)    Ensembl 4798
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM stil No data available
    MARKER RELATIONSHIPS
    stil Contained in: [BAC] DKEY-192M14 (1) (order this)
    stil Encodes: [STS] chunp6907
    [cDNA] MGC:110502 (1), MGC:191758 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_173244 (1) 4817 bp
    Genomic GenBank:BX908392 (1) 179577 bp
    Select Tool
    Polypeptide UniProtKB:B5DDH8 (1) 1263 aa
    Sequence Information (all 23)
    ORTHOLOGY for stil ( Chr: 22 )
    CITATIONS (41)