Gene

mcm7

ID

ZDB-GENE-020419-27

Name

minichromosome maintenance complex component 7

Symbol

mcm7 Nomenclature History

Previous Names

chunp6911
MCM7 minichromosome maintenance deficient 7
nyz175 (1)
sr:nyz175 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Acts upstream of or within regulation of cilium assembly. Predicted to be part of MCM complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77442 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mcm7 Human Ortholog

No data available

Associated With mcm7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018525	Mini-chromosome maintenance, conserved site
Domain	IPR001208	MCM domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR027925	MCM, N-terminal domain
Domain	IPR033762	MCM OB domain
Domain	IPR041562	MCM, AAA-lid domain
Family	IPR008050	DNA replication licensing factor Mcm7
Family	IPR031327	Mini-chromosome maintenance protein
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	DNA replication licensing factor Mcm7	MCM, AAA-lid domain	MCM domain	MCM, N-terminal domain	MCM OB domain	Mini-chromosome maintenance, conserved site	Mini-chromosome maintenance protein	Nucleic acid-binding, OB-fold	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q7ZVL6 InterPro	721

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mcm7-201 (1) Ensembl	Ensembl	1,827 nt	Select Tool ZFIN BLAST
mRNA	mcm7-202 (1) Ensembl	Ensembl	441 nt	Select Tool ZFIN BLAST
mRNA	mcm7-203 (1) Ensembl	Ensembl	392 nt	Select Tool ZFIN BLAST
mRNA	mcm7-204 (1) Ensembl	Ensembl	651 nt	Select Tool ZFIN BLAST
mRNA	mcm7-205 (1) Ensembl	Ensembl	1,193 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations