Gene

tpi1a

ID

ZDB-GENE-020416-3

Name

triosephosphate isomerase 1a

Symbol

tpi1a Nomenclature History

Previous Names

DrTPI-A (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have methylglyoxal synthase activity; protein homodimerization activity; and triose-phosphate isomerase activity. Predicted to be involved in several processes, including gluconeogenesis; glyceraldehyde-3-phosphate biosynthetic process; and methylglyoxal biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Is expressed in liver. Orthologous to human TPI1 (triosephosphate isomerase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56599 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpi1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
triosephosphate isomerase deficiency	Alliance	Hemolytic anemia due to triosephosphate isomerase deficiency	615512

Associated With tpi1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR020861	Triosephosphate isomerase, active site
Family	IPR000652	Triosephosphate isomerase
Family	IPR022896	Triosephosphate isomerase, bacterial/eukaryotic
Homologous_superfamily	IPR013785	Aldolase-type TIM barrel
Homologous_superfamily	IPR035990	Triosephosphate isomerase superfamily