Gene

sall1a

ID

ZDB-GENE-020228-2

Name

spalt-like transcription factor 1a

Symbol

sall1a Nomenclature History

Previous Names

sall1 (1)
spa1a (1)
spalt1a (1)
cb896 (1)
id:ibd5077
sb:eu809

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic pectoral fin morphogenesis and positive regulation of fibroblast growth factor receptor signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including fin; nervous system; neural keel; neural tube; and tail bud. Human ortholog(s) of this gene implicated in Townes-Brocks syndrome; middle lobe syndrome; and renal Wilms' tumor. Orthologous to human SALL1 (spalt like transcription factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

26 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb896 (16 images)
eu809 (28 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sall1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Townes-Brocks syndrome	Alliance	Townes-Brocks branchiootorenal-like syndrome	107480
Townes-Brocks syndrome	Alliance	Townes-Brocks syndrome 1	107480

Associated With sall1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR051565	Sal C2H2-type zinc-finger
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Sal C2H2-type zinc-finger	Zinc finger C2H2 superfamily	Zinc finger C2H2-type
UniProtKB:A0A1D5NSE4	InterPro	1217
UniProtKB:F1QI36	InterPro	1313

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sall1a-201 (1) Ensembl	Ensembl	6,552 nt	Select Tool ZFIN BLAST
mRNA	sall1a-202 (1) Ensembl	Ensembl	6,651 nt	Select Tool ZFIN BLAST
mRNA	sall1a-203 (1) Ensembl	Ensembl	3,974 nt	Select Tool ZFIN BLAST
mRNA	sall1a-204 (1) Ensembl	Ensembl	4,091 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations