Gene

gria3a

ID

ZDB-GENE-020125-5

Name

glutamate receptor, ionotropic, AMPA 3a

Symbol

gria3a Nomenclature History

Previous Names

glur3a
gria3.1
zfGRIA3[a] (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to localize to AMPA glutamate receptor complex; dendritic spine; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 94. Is expressed in nervous system. Orthologous to human GRIA3 (glutamate ionotropic receptor AMPA type subunit 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hwang et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gria3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
syndromic X-linked intellectual disability 94	Alliance	Intellectual developmental disorder, X-linked syndromic, Wu type	300699

Associated With gria3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001320	Ionotropic glutamate receptor, C-terminal
Domain	IPR001828	Receptor, ligand binding region
Domain	IPR019594	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Family	IPR001508	Ionotropic glutamate receptor, metazoa
Family	IPR015683	Ionotropic glutamate receptor
Homologous_superfamily	IPR028082	Periplasmic binding protein-like I

Domain Details Per Protein

Protein	Length	Ionotropic glutamate receptor	Ionotropic glutamate receptor, C-terminal	Ionotropic glutamate receptor, L-glutamate and glycine-binding domain	Ionotropic glutamate receptor, metazoa	Periplasmic binding protein-like I	Receptor, ligand binding region
UniProtKB:A0A8M2BC95 InterPro	903
UniProtKB:Q71E61 InterPro	886
UniProtKB:A0A8M9Q861 InterPro	767
UniProtKB:A0A8M2BCE2 InterPro	772
UniProtKB:A0A8M2BC92 InterPro	886
UniProtKB:A2CG69 InterPro	886

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gria3a-201 (1) Ensembl	Ensembl	2,868 nt	Select Tool ZFIN BLAST
mRNA	gria3a-202 (1) Ensembl	Ensembl	456 nt	Select Tool ZFIN BLAST
ncRNA	gria3a-003 (1) Ensembl	Ensembl	757 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations