Gene
gria3a
- ID
- ZDB-GENE-020125-5
- Name
- glutamate receptor, ionotropic, AMPA 3a
- Symbol
- gria3a Nomenclature History
- Previous Names
-
- glur3a
- gria3.1
- zfGRIA3[a] (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have AMPA glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to localize to AMPA glutamate receptor complex; dendritic spine; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 94. Is expressed in nervous system. Orthologous to human GRIA3 (glutamate ionotropic receptor AMPA type subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hwang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic X-linked intellectual disability 94 | Alliance | Intellectual developmental disorder, X-linked syndromic, Wu type | 300699 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BC95
|
903 | ||||||
|
UniProtKB:Q71E61
|
886 | ||||||
|
UniProtKB:A0A8M9Q861
|
767 | ||||||
|
UniProtKB:A0A8M2BCE2
|
772 | ||||||
|
UniProtKB:A0A8M2BC92
|
886 | ||||||
|
UniProtKB:A2CG69
|
886 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gria3a-201
(1)
|
Ensembl | 2,868 nt | ||
| mRNA |
gria3a-202
(1)
|
Ensembl | 456 nt | ||
| ncRNA |
gria3a-003
(1)
|
Ensembl | 757 nt |
Interactions and Pathways
No data available
Plasmids