ZFIN ID: ZDB-GENE-020102-1
Gene Name: chemokine (C-X-C motif) receptor 4a
Gene Symbol: cxcr4a    Nomenclature History

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Previous Name: cb824 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including ameboidal-type cell migration; embryonic viscerocranium morphogenesis; and vasculature development. Predicted to localize to the external side of plasma membrane. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Is expressed in several structures, including brain; endoderm; mesoderm; tail bud; and vasculature. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
Genome Resources: Alliance (1),  Gene:140747 (1),  Ensembl(GRCz11):ENSDARG00000057633 (2)
GENE EXPRESSION
All Expression Data: 51 figures from 31 publications
Directly Submitted Expression Data: 6 figures (27 images) from Thisse et al., 2001 [cb824]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a169 Small Deletion Unknown Frameshift CRISPR
s421 Unknown Unknown Unknown
sa1098 Point Mutation Unknown Premature Stop ENU
um20 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
um21 Indel Unknown Frameshift, Premature Stop
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-cxcr4a 1
CRISPR2-cxcr4a 1
CRISPR3-cxcr4a 1
CRISPR4-cxcr4a 1
CRISPR5-cxcr4a 1
MO1-cxcr4a N/A 8
MO2-cxcr4a N/A 4
MO3-cxcr4a N/A 2
MO4-cxcr4a N/A 1
MO5-cxcr4a N/A 2
MO6-cxcr4a N/A 1
MO7-cxcr4a N/A 1
MO8-cxcr4a N/A 3
DISEASE ASSOCIATED WITH cxcr4a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
WHIM syndrome Alliance WHIM syndrome 193670
Myelokathexis, isolated
DISEASE ASSOCIATED WITH cxcr4a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell migration involved in sprouting angiogenesis (more)
Cellular Component integral component of membrane (more)
Molecular Function chemokine receptor activity (more)
GO Terms (all 27)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000355 Chemokine receptor family
Family IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2
Domain IPR017452 GPCR, rhodopsin-like, 7TM
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cxcr4a-201 (1)    Ensembl 1636
cxcr4a-202 (1)    Ensembl 1227
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cxcr4a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
TgBAC(cxcr4a:Citrine) cxcr4a Citrine Danio rerio 1 2
tgbac(cxcr4a:h2az2a-mcherry) cxcr4a h2az2amCherry Danio rerio 1 1
tgbac(cxcr4b:cxcr4a) cxcr4b cxcr4a Danio rerio 1 1
MARKER RELATIONSHIPS
cxcr4a Contained in: [BAC] CH73-268G8 (1)
cxcr4a Encodes: [EST] cb824 (1)
[cDNA] MGC:56609 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131882 (1) 1537 bp
Genomic GenBank:CU639412 (1) 58624 bp
Select Tool
Polypeptide UniProtKB:F1QCB2 (1) 360 aa
Sequence Information (all 15)
ORTHOLOGY for cxcr4a ( Chr: 6 )
CITATIONS (96)