Gene

cxcr4a

ID
ZDB-GENE-020102-1
Name
chemokine (C-X-C motif) receptor 4a
Symbol
cxcr4a Nomenclature History
Previous Names
  • cb824 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable chemokine receptor activity. Acts upstream of with a positive effect on G1/S transition of mitotic cell cycle and cilium assembly. Acts upstream of or within with a positive effect on Kupffer's vesicle development. Acts upstream of or within several processes, including embryonic morphogenesis; neural crest cell migration involved in sympathetic nervous system development; and vasculature development. Predicted to be located in early endosome and membrane. Is expressed in several structures, including brain; endoderm; mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
60 figures from 40 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
35 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcr4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
WHIM syndrome 1 Alliance Myelokathexis, isolated 193670
WHIM syndrome 1 Alliance WHIM syndrome 1 193670
Associated With cxcr4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000355 Chemokine receptor family
Family IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2
Domain Details Per Protein
Protein Length Chemokine receptor family CXC chemokine receptor 4/atypical chemokine receptor 2 GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:Q7ZU02 360
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cxcr4a-201 (1) Ensembl 1,636 nt
mRNA cxcr4a-202 (1) Ensembl 1,227 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations