Gene
cxcr4a
- ID
- ZDB-GENE-020102-1
- Name
- chemokine (C-X-C motif) receptor 4a
- Symbol
- cxcr4a Nomenclature History
- Previous Names
-
- cb824 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable chemokine receptor activity. Acts upstream of with a positive effect on G1/S transition of mitotic cell cycle and cilium assembly. Acts upstream of or within with a positive effect on Kupffer's vesicle development. Acts upstream of or within several processes, including embryonic morphogenesis; neural crest cell migration involved in sympathetic nervous system development; and vasculature development. Predicted to be located in early endosome and membrane. Is expressed in several structures, including brain; endoderm; mesoderm; tail bud; and vasculature. Human ortholog(s) of this gene implicated in several diseases, including WHIM syndrome; bone disease (multiple); hematologic cancer (multiple); pancreatic adenocarcinoma; and prostate cancer. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 60 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb824 (27 images)
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| WHIM syndrome 1 | Alliance | Myelokathexis, isolated | 193670 |
| WHIM syndrome 1 | Alliance | WHIM syndrome 1 | 193670 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chemokine receptor family | CXC chemokine receptor 4/atypical chemokine receptor 2 | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZU02
|
360 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcr4a-201
(1)
|
Ensembl | 1,636 nt | ||
| mRNA |
cxcr4a-202
(1)
|
Ensembl | 1,227 nt |
Interactions and Pathways
No data available
Plasmids
No data available