Gene

atic

ID
ZDB-GENE-011212-4
Name
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Symbol
atic Nomenclature History
Previous Names
  • cb72 (1)
  • id:ibd1333
  • wu:fb50b10
  • wu:fb58a11
  • wu:fi76g09
  • wu:fy77g01
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Predicted to localize to cytosol. Is expressed in several structures, including digestive system; immature eye; nervous system; neural crest; and yolk. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase).
Genome Resources
Note
None
Expression
All Expression Data
17 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atic Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
AICA-ribosiduria due to ATIC deficiency 608688
Associated With atic Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011607 Methylglyoxal synthase-like domain
Family IPR002695 Bifunctional purine biosynthesis protein PurH-like
Homologous_superfamily IPR016193 Cytidine deaminase-like
Homologous_superfamily IPR024050 AICAR transformylase, insert domain superfamily
Homologous_superfamily IPR024051 AICAR transformylase, duplicated domain superfamily
Homologous_superfamily IPR036914 Methylglyoxal synthase-like domain superfamily
Domain Details Per Protein
Protein Length AICAR transformylase, duplicated domain superfamily AICAR transformylase, insert domain superfamily Bifunctional purine biosynthesis protein PurH-like Cytidine deaminase-like Methylglyoxal synthase-like domain Methylglyoxal synthase-like domain superfamily
UniProtKB:A2CEW4 590
UniProtKB:B3DKL0 590
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations