Gene
mt-nd5
- ID
- ZDB-GENE-011205-12
- Name
- NADH dehydrogenase 5, mitochondrial
- Symbol
- mt-nd5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: MT Mapping Details/Browsers
- Description
- Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in electron transport coupled proton transport; mitochondrial electron transport, NADH to ubiquinone; and mitochondrial respiratory chain complex I assembly. Predicted to act upstream of or within ATP synthesis coupled electron transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Is expressed in muscle and skeletal muscle. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Leigh disease; and MELAS syndrome. Orthologous to human MT-ND5 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001516 | NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal |
| Domain | IPR001750 | NADH:quinone oxidoreductase/Mrp antiporter, transmembrane domain |
| Domain | IPR010934 | NADH dehydrogenase subunit 5, C-terminal |
| Family | IPR003945 | NADH-quinone oxidoreductase, chain 5-like |
| Family | IPR018393 | NADH-plastoquinone oxidoreductase, chain 5 subgroup |
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Domain Details Per Protein
| Protein | Additional Resources | Length | NADH dehydrogenase subunit 5, C-terminal | NADH-plastoquinone oxidoreductase, chain 5 subgroup | NADH-quinone oxidoreductase, chain 5-like | NADH:quinone oxidoreductase/Mrp antiporter, transmembrane domain | NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9MIY0 | InterPro | 606 |
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- Genome Browsers
- No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mt-nd5-201
(1)
|
Ensembl | 1,821 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| Genomic | GenBank:AC024175 (1) | 16596 nt | ||
| Polypeptide | UniProtKB:Q9MIY0 (1) | 606 aa |
- Shi, L., Zhang, A., Liu, H., Wang, H. (2023) Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish. International Journal of Molecular Sciences. 24(10):
- Van Haute, L., O'Connor, E., Díaz-Maldonado, H., Munro, B., Polavarapu, K., Hock, D.H., Arunachal, G., Athanasiou-Fragkouli, A., Bardhan, M., Barth, M., Bonneau, D., Brunetti-Pierri, N., Cappuccio, G., Caruana, N.J., Dominik, N., Goel, H., Helman, G., Houlden, H., Lenaers, G., Mention, K., Murphy, D., Nandeesh, B., Olimpio, C., Powell, C.A., Preethish-Kumar, V., Procaccio, V., Rius, R., Rebelo-Guiomar, P., Simons, C., Vengalil, S., Zaki, M.S., Ziegler, A., Thorburn, D.R., Stroud, D.A., Maroofian, R., Christodoulou, J., Gustafsson, C., Nalini, A., Lochmüller, H., Minczuk, M., Horvath, R. (2023) TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Nature communications. 14:10091009
- Song, Y., Chen, W., Zhu, B., Ge, W. (2022) Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary. Frontiers in cell and developmental biology. 9:750888
- Lee, J.Y., Park, H., Lim, W., Song, G. (2021) Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. The Science of the total environment. 771:145445
- Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):
- Watchon, M., Luu, L., Robinson, K.J., Yuan, K.C., De Luca, A., Suddull, H.J., Tym, M.C., Guillemin, G.J., Cole, N.J., Nicholson, G.A., Chung, R.S., Lee, A., Laird, A.S. (2021) Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo. Molecular brain. 14:128
- Tseng, Y.T., Li, S.W., HuangFu, W.C., Yen, Y., Liu, I.H. (2020) The single nucleotide variant at c.662A>G in human RRM2B is a loss-of-function mutation. Molecular genetics & genomic medicine. 8(11):e1497
- Zhou, Z., Zheng, L., Tang, C., Chen, Z., Zhu, R., Peng, X., Wu, X., Zhu, P. (2020) Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in Physiology. 11:565307
- Chen, D., Zhang, Z., Chen, C., Yao, S., Yang, Q., Li, F., He, X., Ai, C., Wang, M., Guan, M.X. (2019) Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Nucleic acids research. 47(10):5341-5355
- Li, X., Zha, X., Wang, Y., Jia, R., Hu, B., Zhao, B. (2018) Toxic effects and foundation of proton radiation on the early-life stage of zebrafish development. Chemosphere. 200:302-312
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