Gene
jag1a
- ID
- ZDB-GENE-011128-2
- Name
- jagged canonical Notch ligand 1a
- Symbol
- jag1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; regulation of non-canonical NF-kappaB signal transduction; and thyroid gland development. Is active in plasma membrane. Is expressed in several structures, including digestive system; lens placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb243 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| kz4 | Allele with one deletion | Unknown | Unknown | not specified | |
| la011260Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028179Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa168 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa1989 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11248 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39691 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45084 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko992a | Allele with one deletion | Unknown | Unknown | CRISPR | |
| zko992b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-jag1a | (3) | |
| CRISPR2-jag1a | Zhang et al., 2024 | |
| MO1-jag1a | N/A | (5) |
| MO2-jag1a | N/A | (4) |
| MO3-jag1a | N/A | (2) |
| MO4-jag1a | N/A | (2) |
| MO5-jag1a | N/A | Lu et al., 2021 |
| MO6-jag1a | N/A | Bai et al., 2023 |
| MO7-jag1a | N/A | Bai et al., 2023 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alagille syndrome | Alliance | Alagille syndrome 1 | 118450 |
| tetralogy of Fallot | Alliance | Tetralogy of Fallot | 187500 |
| Charcot-Marie-Tooth disease, axonal, type 2HH | 619574 | ||
| ?Deafness, congenital heart defects, and posterior embryotoxon | 617992 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Jagged/Serrate protein | NOTCH1 EGF-like calcium-binding domain | Notch ligand, N-terminal domain | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8JKQ5 | InterPro | 1253 | |||||||||||
| UniProtKB:Q90Y57 | InterPro | 1242 | |||||||||||
| UniProtKB:A0A8M2BFK4 | InterPro | 1252 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(jag1a:mNeonGreen) |
|
| 1 | Sánchez-Iranzo et al., 2022 | |
| TgBAC(jag1a:mScarlet) |
|
| 1 | Sánchez-Iranzo et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-210M15 | ZFIN Curated Data | |
| Encodes | EST | cb243 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:193563 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131861 (1) | 6669 nt | ||
| Genomic | GenBank:CU138540 (2) | 163222 nt | ||
| Polypeptide | UniProtKB:B8JKQ5 (1) | 1253 aa |
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Zhang, Y., Liu, Y., Qin, W., Zheng, S., Xiao, J., Xia, X., Yuan, X., Zeng, J., Shi, Y., Zhang, Y., Ma, H., Varshney, G.K., Fei, J.F., Liu, Y. (2024) Cytosine base editors with increased PAM and deaminase motif flexibility for gene editing in zebrafish. Nature communications. 15:95269526
- Bai, M.R., Pei, H.Y., Zhou, Y., Song, H.L., Pan, W.H., Gong, Y.M., Wu, W.J., Yu, W.W., Cui, M.M., Gu, B.L., Chu, X., Cai, W. (2023) Association analysis and functional follow-up identified common variants of JAG1 accounting for risk to biliary atresia. Frontiers in genetics. 14:11868821186882
- Cotellessa, L., Marelli, F., Duminuco, P., Adamo, M., Papadakis, G.E., Bartoloni, L., Sato, N., Lang-Muritano, M., Troendle, A., Dhillo, W.S., Morelli, A., Guarnieri, G., Pitteloud, N., Persani, L., Bonomi, M., Giacobini, P., Vezzoli, V. (2023) Defective Jagged1 signaling impacts GnRH development and contributes to congenital hypogonadotropic hypogonadism. JCI insight. 8(5):
- Kondo, M., Kimura, K., Kobayashi-Sun, J., Yamamori, S., Taniguchi, M., Traver, D., Kobayashi, I. (2023) The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 26:106508106508
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Kraus, J.M., Giovannone, D., Rydzik, R., Balsbaugh, J.L., Moss, I.L., Schwedler, J.L., Bertrand, J.Y., Traver, D., Hankenson, K.D., Crump, J.G., Youngstrom, D.W. (2022) Notch signaling enhances bone regeneration in the zebrafish mandible. Development (Cambridge, England). 149(5)
- Kugler, E.C., Frost, J., Silva, V., Plant, K., Chhabria, K., Chico, T.J.A., Armitage, P.A. (2022) Zebrafish Vascular Quantification (ZVQ): a tool for quantification of three-dimensional zebrafish cerebrovascular architecture by automated image analysis. Development (Cambridge, England). 149(3):
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Sánchez-Iranzo, H., Halavatyi, A., Diz-Muñoz, A. (2022) Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord. eLIFE. 11:
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