Gene

jag1a

ID
ZDB-GENE-011128-2
Name
jagged canonical Notch ligand 1a
Symbol
jag1a Nomenclature History
Previous Names
  • jag1
  • cb243 (1)
  • jagged1a (1)
  • sb:cb243
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable Notch binding activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including hematopoietic stem cell differentiation; regulation of non-canonical NF-kappaB signal transduction; and thyroid gland development. Is active in plasma membrane. Is expressed in several structures, including digestive system; lens placode; nervous system; neural keel; and neural tube. Human ortholog(s) of this gene implicated in Alagille syndrome; Charcot-Marie-Tooth disease; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 17 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
kz4Allele with one deletionUnknownUnknownnot specified
la011260TgTransgenic insertionUnknownUnknownDNA
la028179TgTransgenic insertionUnknownUnknownDNA
sa168Allele with one point mutationUnknownPremature StopENU
sa1989Allele with one point mutationUnknownSplice SiteENU
sa11248Allele with one point mutationUnknownPremature StopENU
sa39691Allele with one point mutationUnknownPremature StopENU
sa45084Allele with one point mutationUnknownPremature StopENU
zko992aAllele with one deletionUnknownUnknownCRISPR
zko992bAllele with one deletionUnknownUnknownCRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With jag1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alagille syndrome Alliance Alagille syndrome 1 118450
tetralogy of Fallot Alliance Tetralogy of Fallot 187500
Charcot-Marie-Tooth disease, axonal, type 2HH 619574
?Deafness, congenital heart defects, and posterior embryotoxon 617992
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Associated With jag1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001007 VWFC domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
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Domain Details Per Protein
Protein Additional Resources Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Jagged/Serrate protein NOTCH1 EGF-like calcium-binding domain Notch ligand, N-terminal domain VWFC domain
UniProtKB:B8JKQ5 InterPro 1253
UniProtKB:Q90Y57 InterPro 1242
UniProtKB:A0A8M2BFK4 InterPro 1252
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 1
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA jag1a-201 (1) Ensembl 3,729 nt
mRNA jag1a-202 (1) Ensembl 6,678 nt
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Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
TgBAC(jag1a:mNeonGreen)
  • jag1a
  • Danio rerio
1Sánchez-Iranzo et al., 2022
TgBAC(jag1a:mScarlet)
  • jag1a
  • Danio rerio
1Sánchez-Iranzo et al., 2022
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Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-210M15ZFIN Curated Data
EncodesESTcb243Thisse et al., 2001
EncodescDNAMGC:193563ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanJAG120
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
MouseJag12
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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