Gene

tfe3a

ID

ZDB-GENE-010919-2

Name

transcription factor binding to IGHM enhancer 3a

Symbol

tfe3a Nomenclature History

Previous Names

cb873 (1)
zgc:109815

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in transcription, DNA-templated. Predicted to localize to nucleoplasm. Human ortholog(s) of this gene implicated in renal cell carcinoma. Is expressed in several structures, including hindbrain neural plate; intermediate cell mass of mesoderm; solid lens vesicle; ventral mesoderm; and yolk syncytial layer. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb873 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tfe3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
renal cell carcinoma	Alliance	Renal cell carcinoma, papillary, 1	300854
		Intellectual developmental disorder, X-linked syndromic, with pigmentary mosaicism and coarse facies	301066

Associated With tfe3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR021802	MiT/TFE transcription factors, C-terminal
Domain	IPR031867	MiT/TFE transcription factors, N-terminal
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily