Gene

pklr

ID
ZDB-GENE-010907-1
Name
pyruvate kinase L/R
Symbol
pklr Nomenclature History
Previous Names
  • wu:fd15e01
  • wu:fi37e08
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and pyruvate kinase activity. Acts upstream of or within liver development. Is expressed in digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
23 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pklr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital nonspherocytic hemolytic anemia 2 Alliance Anemia, congenital, nonspherocytic hemolytic, 2, pyruvate kinase deficient 266200
[Adenosine triphosphate, elevated, of erythrocytes] 102900
1 - 2 of 2
Associated With pklr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018209 Pyruvate kinase, active site
Domain IPR015793 Pyruvate kinase, barrel
Domain IPR015795 Pyruvate kinase, C-terminal
Family IPR001697 Pyruvate kinase
Homologous_superfamily IPR011037 Pyruvate kinase-like, insert domain superfamily
1 - 5 of 9 Show all
Domain Details Per Protein
Protein Additional Resources Length Pyruvate kinase Pyruvate kinase, active site Pyruvate kinase, barrel Pyruvate kinase, C-terminal Pyruvate kinase, C-terminal domain superfamily Pyruvate kinase, insert domain superfamily Pyruvate kinase-like domain superfamily Pyruvate kinase-like, insert domain superfamily Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
UniProtKB:Q7SXK3 InterPro 538
UniProtKB:A0A8M9NZ14 InterPro 527
UniProtKB:A0AB32T4X3 InterPro 469
1 - 3 of 3
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pklr-201 (1)
Ensembl
Ensembl 1,787 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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