Gene

pklr

ID
ZDB-GENE-010907-1
Name
pyruvate kinase L/R
Symbol
pklr Nomenclature History
Previous Names
  • wu:fd15e01
  • wu:fi37e08
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have kinase activity; metal ion binding activity; and pyruvate kinase activity. Involved in liver development. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Is expressed in female organism; heart; intestine; liver; and male organism. Orthologous to human PKLR (pyruvate kinase L/R).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pklr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pyruvate kinase deficiency of red cells Alliance Pyruvate kinase deficiency 266200
Adenosine triphosphate, elevated, of erythrocytes 102900
Associated With pklr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018209 Pyruvate kinase, active site
Domain IPR015793 Pyruvate kinase, barrel
Domain IPR015795 Pyruvate kinase, C-terminal
Family IPR001697 Pyruvate kinase
Homologous_superfamily IPR011037 Pyruvate kinase-like, insert domain superfamily
Homologous_superfamily IPR015806 Pyruvate kinase, insert domain superfamily
Homologous_superfamily IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
Homologous_superfamily IPR036918 Pyruvate kinase, C-terminal domain superfamily
Homologous_superfamily IPR040442 Pyruvate kinase-like domain superfamily
Domain Details Per Protein
Protein Length Pyruvate kinase Pyruvate kinase, active site Pyruvate kinase, barrel Pyruvate kinase, C-terminal Pyruvate kinase, C-terminal domain superfamily Pyruvate kinase, insert domain superfamily Pyruvate kinase-like domain superfamily Pyruvate kinase-like, insert domain superfamily Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
UniProtKB:A7MCK8 180
UniProtKB:E7F9R3 538
UniProtKB:Q7SXK3 538
UniProtKB:A8KC20 538
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations