Gene

angpt1

ID

ZDB-GENE-010817-1

Name

angiopoietin 1

Symbol

angpt1 Nomenclature History

Previous Names

ang1 (1)
wu:fc76g06

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have receptor tyrosine kinase binding activity. Involved in blood vessel development and brain development. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. Is expressed in several structures, including brain; heart tube; hypochord; medial longitudinal fasciculus; and ventral mesenchyme. Orthologous to human ANGPT1 (angiopoietin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With angpt1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Angioedema, hereditary, 5	619361

Associated With angpt1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020837	Fibrinogen, conserved site
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Family	IPR050373	Fibrinogen C-terminal domain-containing protein
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal