Gene

f7

ID
ZDB-GENE-010814-1
Name
coagulation factor VII
Symbol
f7 Nomenclature History
Previous Names
  • wu:fb59f04
  • zgc:109870
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and serine-type endopeptidase activity. Involved in blood coagulation, fibrin clot formation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including acute pancreatitis; artery disease (multiple); diabetes mellitus (multiple); inherited blood coagulation disease (multiple); and obesity. Is expressed in blood plasma; liver; and yolk syncytial layer. Orthologous to human F7 (coagulation factor VII).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Khandekar et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With f7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Factor VII deficiency 227500
{Myocardial infarction, decreased susceptibility to} 608446
Associated With f7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018114 Serine proteases, trypsin family, histidine active site
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Domain IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
Domain IPR000742 EGF-like domain
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR001881 EGF-like calcium-binding domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Family IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
Family IPR033190 Coagulation factor VII
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR017857 Coagulation factor-like, Gla domain superfamily
Homologous_superfamily IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Domain Details Per Protein
Protein Length Coagulation factor-like, Gla domain superfamily Coagulation factor VII EGF-like calcium-binding domain EGF-like domain Gamma-carboxyglutamic acid-rich (GLA) domain Gamma-carboxyglutamic acid-rich (GLA) domain superfamily Peptidase S1A, chymotrypsin family Peptidase S1A, coagulation factor VII/IX/X/C/Z Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, histidine active site Serine proteases, trypsin family, serine active site
UniProtKB:F1QFP3 433
UniProtKB:Q90YK1 433
UniProtKB:Q504H3 433
UniProtKB:Q8JHD0 433
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations