Gene
sim2
- ID
- ZDB-GENE-010803-1
- Name
- SIM bHLH transcription factor 2
- Symbol
- sim2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Is expressed in diencephalon; midbrain; pharyngeal arch; and presumptive diencephalon. Orthologous to human SIM2 (SIM bHLH transcription factor 2).
- Genome Resources
-
- Alliance (1)
- Gene:114450 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
-
- MGC:76842 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Al-Kurbi et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013655 | PAS fold-3 |
| Domain | IPR013767 | PAS fold |
| Family | IPR001067 | Nuclear translocator |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear translocator | PAC motif | PAS domain | PAS domain superfamily | PAS fold | PAS fold-3 |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8UVV3
|
585 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance