Gene
bcl2l1
- ID
- ZDB-GENE-010730-1
- Name
- BCL2 like 1
- Symbol
- bcl2l1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway; thyroid gland development; and tissue homeostasis. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including blood island; endocrine system; extension; immune system; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1021 (10 images)
- IMAGE:6910760 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Porreca et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010762Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15253 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-bcl2l1 | N/A | (2) |
| MO2-bcl2l1 | N/A | Chen et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-X | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90Z98 | InterPro | 238 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bcl2l1-201
(1)
|
Ensembl | 2,025 nt | ||
| mRNA |
bcl2l1-202
(1)
|
Ensembl | 1,979 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(rag2:EGFP-bcl2l1) |
|
| 1 | Harrold et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-192I18 | ZFIN Curated Data | |
| Encodes | EST | cb1021 | Thisse et al., 2001 | |
| Encodes | EST | IMAGE:6910760 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55232 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86578 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192331 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131807 (1) | 1942 nt | ||
| Genomic | GenBank:CR788311 (1) | 147664 nt | ||
| Polypeptide | UniProtKB:Q90Z98 (1) | 238 aa |
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
- Xu, W., Liu, X., Li, J., Sun, C., Chen, L., Zhou, J., Li, K., Li, Q., Meng, A., Sun, Q. (2024) ULI-ssDRIP-seq revealed R-loop dynamics during vertebrate early embryogenesis. Cell insight. 3:100179100179
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
- Liang, F., Lu, X., Wu, B., Yang, Y., Qin, W. (2023) Nucleolar Protein 56 Deficiency in Zebrafish Leads to Developmental Abnormalities and Anemia via p53 and JAK2-STAT3 Signaling. Biology. 12(4):
- Morgan, K.J., Doggett, K., Geng, F., Mieruszynski, S., Whitehead, L., Smith, K.A., Hogan, B.M., Simons, C., Baillie, G.J., Molania, R., Papenfuss, A.T., Hall, T.E., Ober, E.A., Stainier, D.Y.R., Gong, Z., Heath, J.K. (2023) ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. eLIFE. 12:
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) Deciphering the pathogenesis of retinopathy associated with carnitine palmitoyltransferase I deficiency in zebrafish model. Biochemical and Biophysical Research Communications. 664:100107100-107
- Dong, R., Zhang, Y., Chen, S., Wang, H., Hu, K., Zhao, H., Tian, Q., Zeng, K., Wang, S., Han, L. (2022) Identification of key pharmacodynamic markers of American ginseng against heart failure based on metabolomics and zebrafish model. Frontiers in pharmacology. 13:909084
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Zhang, Q., Li, T., Lin, J., Zhang, Y., Li, F., Chen, X., Wang, X., Li, Q. (2022) Deficiency of nde1 in zebrafish induces brain inflammatory responses and autism-like behavior. iScience. 25:103876
- Franke, M., De la Calle-Mustienes, E., Neto, A., Almuedo-Castillo, M., Irastorza-Azcarate, I., Acemel, R.D., Tena, J.J., Santos-Pereira, J.M., Gómez-Skarmeta, J.L. (2021) CTCF knockout in zebrafish induces alterations in regulatory landscapes and developmental gene expression. Nature communications. 12:5415
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