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Gene

etv6

ID
ZDB-GENE-010727-1
Name
ETS variant transcription factor 6
Symbol
etv6 Nomenclature History
Previous Names
  • id:ibd2308
  • ztel (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within embryonic hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including brain; germ ring; intermediate cell mass of mesoderm; mesoderm; and renal system. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and thrombocytopenia. Orthologous to human ETV6 (ETS variant transcription factor 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Rasighaemi et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With etv6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
Thrombocytopenia 5 616216
Associated With etv6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000418 Ets domain
Domain IPR003118 Pointed domain
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Ets domain Pointed domain Sterile alpha motif/pointed domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q90ZS9 444
UniProtKB:B2GTA2 444
UniProtKB:Q7ZU22 444
Transcripts
Genome Browsers
No data available
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations