Gene
dlg1a
- ID
- ZDB-GENE-010724-8
- Name
- discs large MAGUK scaffold protein 1a
- Symbol
- dlg1a Nomenclature History
- Previous Names
-
- dlg1
- SAP-97A (1)
- wu:fc34d02
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable ionotropic glutamate receptor binding activity; phosphatase binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; epithelial structure maintenance; and negative regulation of G1/S transition of mitotic cell cycle. Predicted to be located in anchoring junction; apical plasma membrane; and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including basolateral plasma membrane; neuromuscular junction; and postsynaptic density membrane. Is expressed in several structures, including heart; nervous system; neural tube; pigment cell; and trigeminal placode. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55810 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR004172 | L27 domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR015143 | L27-1 |
| Domain | IPR019583 | Disks large homolog 1-4, PDZ-associated domain |
| Domain | IPR019590 | Disks large homologue 1, N-terminal PEST domain |
| Family | IPR016313 | Disks large 1-like |
| Family | IPR050614 | Synaptic Scaffolding LAP/MAGUK Families |
| Family | IPR050716 | Membrane-associated guanylate kinase |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036892 | L27 domain superfamily |
Domain Details Per Protein
Interactions and Pathways
No data available
Plasmids
No data available