Gene

copb2

ID

ZDB-GENE-010724-7

Name

COPI coat complex subunit beta 2

Symbol

copb2 Nomenclature History

Previous Names

dop
dopey
sb:cb121
wu:fb30f06

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have structural molecule activity. Involved in notochord development and somite development. Predicted to localize to COPI vesicle coat. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; fin; and nervous system. Orthologous to human COPB2 (COPI coat complex subunit beta 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb121 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With copb2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal recessive microcephaly 19	Alliance	?Microcephaly 19, primary, autosomal recessive	617800
		Osteoporosis, childhood- or juvenile-onset, with developmental delay	619884

Associated With copb2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006692	Coatomer, WD associated region
Family	IPR016453	Coatomer beta' subunit (COPB2)
Homologous_superfamily	IPR011044	Quinoprotein amine dehydrogenase, beta chain-like
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat

Domain Details Per Protein

Protein	Length	Coatomer beta' subunit (COPB2)	Coatomer, WD associated region	G-protein beta WD-40 repeat	Quinoprotein amine dehydrogenase, beta chain-like	WD40 repeat	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q6JWU7 InterPro	934

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	copb2-201 (1) Ensembl	Havana	3218 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	copb2-002 (1) Ensembl	Havana	631 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	copb2-003 (1) Ensembl	Havana	1024 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations