Gene
twsg1a
- ID
- ZDB-GENE-010509-2
- Name
- twisted gastrulation BMP signaling modulator 1a
- Symbol
- twsg1a Nomenclature History
- Previous Names
-
- tsg
- tsga (1)
- fi23f01
- wu:fi23f01
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Acts upstream of or within blood vessel development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa33059 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR006761 | Twisted gastrulation (Tsg) protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Twisted gastrulation (Tsg) protein |
|---|---|---|---|
| UniProtKB:Q9DGH0 | InterPro | 217 | |
| UniProtKB:B1WB83 | InterPro | 217 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
twsg1a-201
(1)
|
Ensembl | 3,485 nt | ||
| mRNA |
twsg1a-202
(1)
|
Ensembl | 5,454 nt | ||
| mRNA |
twsg1a-203
(1)
|
Ensembl | 3,826 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-104P2 | ZFIN Curated Data | |
| Encodes | EST | fi23f01 | Scott et al., 2001 | |
| Encodes | cDNA | MGC:55382 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174802 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192211 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131797 (1) | 3824 nt | ||
| Genomic | GenBank:CU570683 (2) | 37137 nt | ||
| Polypeptide | UniProtKB:B1WB83 (1) | 217 aa |
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Fierro, J., Haynes, D.R., Washbourne, P. (2018) 4.1Ba is necessary for glutamatergic synapse formation in the sensorimotor circuit of developing zebrafish. PLoS One. 13:e0205255
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Little, S.C., and Mullins, M.C. (2004) Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development (Cambridge, England). 131(23):5825-5835
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Graf, D., Timmons, P.M., Hitchins, M., Episkopou, V., Moore, G., Ito, T., Fujiyama, A., Fisher, A.G., and Merkenschlager, M. (2001) Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation. Mammalian genome : official journal of the International Mammalian Genome Society. 12(7):554-560
- Scott, I.C., Blitz, I.L., Pappano, W.N., Maas, S.A., Cho, K.W., and Greenspan, D.S. (2001) Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. Nature. 410(6827):475-478
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