Gene

hmga1a

ID

ZDB-GENE-010502-1

Name

high mobility group AT-hook 1a

Symbol

hmga1a Nomenclature History

Previous Names

hmga1
hmgiy
wu:fb12b06
wu:fb18f11
wu:fc19f01
wu:fi38b05
zgc:85677

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have DNA-(apurinic or apyrimidinic site) endonuclease activity. Involved in regulation of RNA splicing. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in DEL; central nervous system; heart; margin; and otic vesicle. Orthologous to human HMGA1 (high mobility group AT-hook 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:113942 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hmga1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Type 2 diabetes mellitus, susceptibility to}	125853

Associated With hmga1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000637	HMG-I/HMG-Y, DNA-binding, conserved site
Conserved_site	IPR017956	AT hook, DNA-binding motif
Family	IPR000116	High mobility group protein HMGA

Domain Details Per Protein

Protein	Length	AT hook, DNA-binding motif	High mobility group protein HMGA	HMG-I/HMG-Y, DNA-binding, conserved site
UniProtKB:Q6NV11 InterPro	101
UniProtKB:E9QD31 InterPro	100

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hmga1a-201 (1) Ensembl	Ensembl	2,593 nt	Select Tool
mRNA	hmga1a-202 (1) Ensembl	Ensembl	733 nt	Select Tool
mRNA	hmga1a-203 (1) Ensembl	Ensembl	814 nt	Select Tool
mRNA	hmga1a-205 (1) Ensembl	Ensembl	782 nt	Select Tool
mRNA	hmga1a-206 (1) Ensembl	Ensembl	964 nt	Select Tool
mRNA	hmga1a-207 (1) Ensembl	Ensembl	405 nt	Select Tool
mRNA	hmga1a-208 (1) Ensembl	Ensembl	2,416 nt	Select Tool ZFIN BLAST
ncRNA	ottdart00000062042 (1) Ensembl	Ensembl	745 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations