Gene
hmga1a
- ID
- ZDB-GENE-010502-1
- Name
- high mobility group AT-hook 1a
- Symbol
- hmga1a Nomenclature History
- Previous Names
-
- hmga1
- hmgiy
- wu:fb12b06
- wu:fb18f11
- wu:fc19f01
- wu:fi38b05
- zgc:85677
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable transcription coregulator activity. Acts upstream of or within regulation of RNA splicing. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in DEL; heart; margin; nervous system; and otic vesicle. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113942 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus, susceptibility to} | 125853 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AT hook, DNA-binding motif | High mobility group protein HMGA | HMG-I/HMG-Y, DNA-binding, conserved site |
|---|---|---|---|---|---|
| UniProtKB:Q6NV11 | InterPro | 101 | |||
| UniProtKB:E9QD31 | InterPro | 100 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmga1a-201
(1)
|
Ensembl | 2,593 nt | ||
| mRNA |
hmga1a-202
(1)
|
Ensembl | 733 nt | ||
| mRNA |
hmga1a-203
(1)
|
Ensembl | 814 nt | ||
| mRNA |
hmga1a-205
(1)
|
Ensembl | 782 nt | ||
| mRNA |
hmga1a-206
(1)
|
Ensembl | 964 nt | ||
| mRNA |
hmga1a-207
(1)
|
Ensembl | 405 nt | ||
| mRNA |
hmga1a-208
(1)
|
Ensembl | 2,416 nt | ||
| ncRNA |
ottdart00000062042
(1)
|
Ensembl | 745 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-250P19 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-226K3 | ZFIN Curated Data | |
| Encodes | EST | fb12b06 | ||
| Encodes | EST | fb18f11 | ||
| Encodes | EST | fi38b05 | ||
| Encodes | EST | fl77d01 | ||
| Encodes | cDNA | MGC:55952 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85677 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113942 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191217 | ZFIN Curated Data |
1 - 10 of 11
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213168 (1) | 2419 nt | ||
| Genomic | GenBank:CR847526 | 152665 nt | ||
| Polypeptide | UniProtKB:Q6NV11 (1) | 101 aa |
- Fogerty, J., Song, P., Boyd, P., Grabinski, S.E., Hoang, T., Reich, A., Cianciolo, L.T., Blackshaw, S., Mumm, J.S., Hyde, D.R., Perkins, B.D. (2022) Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 42(26):5144-5158
- Chen, Z., Zhijie, C., Yuting, Z., Chan, L., Shilin, X., Qichun, Z., Jinying, O., Jing, L., Chaohua, L., Zhixian, M. (2021) The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis. Frontiers in pharmacology. 12:526923
- D'Orazio, F.M., Balwierz, P.J., González, A.J., Guo, Y., Hernández-Rodríguez, B., Wheatley, L., Jasiulewicz, A., Hadzhiev, Y., Vaquerizas, J.M., Cairns, B., Lenhard, B., Müller, F. (2021) Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization. Developmental Cell. 56(5):641-656.e5
- Hoang, T., Wang, J., Boyd, P., Wang, F., Santiago, C., Jiang, L., Yoo, S., Lahne, M., Todd, L.J., Jia, M., Saez, C., Keuthan, C., Palazzo, I., Squires, N., Campbell, W.A., Rajaii, F., Parayil, T., Trinh, V., Kim, D.W., Wang, G., Campbell, L.J., Ash, J., Fischer, A.J., Hyde, D.R., Qian, J., Blackshaw, S. (2020) Gene regulatory networks controlling vertebrate retinal regeneration. Science (New York, N.Y.). 370(6519):
- Cosacak, M.I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., Kizil, C. (2019) Single-Cell Transcriptomics Analyses of Neural Stem Cell Heterogeneity and Contextual Plasticity in a Zebrafish Brain Model of Amyloid Toxicity. Cell Reports. 27:1307-1318.e3
- King, B.L., Rosenstein, M.C., Smith, A.M., Dykeman, C.A., Smith, G.A., Yin, V.P. (2018) RegenDbase: a comparative database of noncoding RNA regulation of tissue regeneration circuits across multiple taxa. NPJ Regenerative medicine. 3:10
- Reisser, M., Palmer, A., Popp, A.P., Jahn, C., Weidinger, G., Gebhardt, J.C.M. (2018) Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development. Nature communications. 9:5218
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Moussavi-Nik, S.H., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R.N., Lardelli, M. (2015) Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human molecular genetics. 24(13):3662-78
- Hartwig, J., Tarbashevich, K., Seggewiß, J., Stehling, M., Bandemer, J., Grimaldi, C., Paksa, A., Groß-Thebing, T., Meyen, D., Raz, E. (2014) Temporal control over the initiation of cell motility by a regulator of G-protein signaling. Proceedings of the National Academy of Sciences of the United States of America. 111(31):11389-94
1 - 10 of 13
Show