Gene
skic2
- ID
- ZDB-GENE-010430-5
- Name
- SKI2 subunit of superkiller complex
- Symbol
- skic2 Nomenclature History
- Previous Names
-
- skiv2l
- fb70b07
- wu:fb70b07
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have RNA helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay. Predicted to localize to Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 2. Orthologous to human SKIV2L (Ski2 like RNA helicase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| trichohepatoenteric syndrome 2 | Alliance | Trichohepatoenteric syndrome 2 | 614602 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR012961 | ATP-dependent RNA helicase Ski2/MTR4, C-terminal |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR025696 | Exosome RNA helicase MTR4-like, beta-barrel domain |
| Domain | IPR040801 | Ski2, N-terminal domain |
| Domain | IPR048392 | Exosome RNA helicase MTR4-like, stalk |
| Family | IPR016438 | ATP-dependent RNA helicase SKI2-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | ATP-dependent RNA helicase SKI2-like | ATP-dependent RNA helicase Ski2/MTR4, C-terminal | DEAD/DEAH box helicase domain | Exosome RNA helicase MTR4-like, beta-barrel domain | Exosome RNA helicase MTR4-like, stalk | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase | Ski2, N-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1LWQ1
|
1230 | |||||||||
|
UniProtKB:F1R881
|
1249 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
skiv2l-201
(1)
|
Havana | 4191 nt | |
| ncRNA |
ottdart00000045245
(1)
|
Havana | 789 nt |
Interactions and Pathways
No data available
Plasmids
No data available