ZFIN is now using GRCz12tu for Genomic Data
Gene
dhfr
- ID
- ZDB-GENE-010406-5
- Name
- dihydrofolate reductase
- Symbol
- dhfr Nomenclature History
- Previous Names
-
- cb595 (1)
- zgc:86637
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables dihydrofolate reductase activity. Acts upstream of or within folic acid metabolic process; heart contraction; and heart development. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior neural tube; hematopoietic system; immature eye; nervous system; and neural plate. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFR (dihydrofolate reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb595 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| megaloblastic anemia | Alliance | Megaloblastic anemia due to dihydrofolate reductase deficiency | 613839 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dihydrofolate reductase | Dihydrofolate reductase domain | Dihydrofolate reductase-like domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q6IQS4 | InterPro | 190 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers