Gene
ncoa2
- ID
- ZDB-GENE-010406-3
- Name
- nuclear receptor coactivator 2
- Symbol
- ncoa2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables nuclear thyroid hormone receptor binding activity. Involved in granulocyte differentiation and primitive hemopoiesis. Acts upstream of or within chordate embryonic development. Predicted to be active in nucleus. Is expressed in several structures, including eye; gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; and prostate adenocarcinoma. Orthologous to human NCOA2 (nuclear receptor coactivator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu757 (1 image)
- af323989 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Zhuravleva et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR010011 | Nuclear receptor coactivator, DUF1518 |
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR013767 | PAS fold |
| Domain | IPR014920 | Nuclear receptor coactivator, Ncoa-type, interlocking |
| Domain | IPR014935 | Nuclear receptor coactivator, receptor-binding domain |
| Domain | IPR028822 | Nuclear receptor coactivator 2, basic helix-loop-helix |
| Domain | IPR032565 | Nuclear receptor coactivator 2/3, DUF4927 |
| Family | IPR017426 | Nuclear receptor coactivator |
| Homologous_superfamily | IPR009110 | Nuclear receptor coactivator, interlocking |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR037077 | Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily |
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Nuclear receptor coactivator | Nuclear receptor coactivator 2/3, DUF4927 | Nuclear receptor coactivator 2, basic helix-loop-helix | Nuclear receptor coactivator, DUF1518 | Nuclear receptor coactivator, interlocking | Nuclear receptor coactivator, Ncoa-type, interlocking | Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily | Nuclear receptor coactivator, receptor-binding domain | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q98TW1
|
1505 | |||||||||||||
|
UniProtKB:E7F5J8
|
1505 | |||||||||||||
|
UniProtKB:A0A8M9PG56
|
1504 | |||||||||||||
|
UniProtKB:F6NH98
|
1435 |
Interactions and Pathways
No data available
Plasmids
No data available