Gene
cldng
- ID
- ZDB-GENE-010328-7
- Name
- claudin g
- Symbol
- cldng Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable identical protein binding activity. Predicted to be involved in bicellular tight junction assembly and calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including digestive system; gonad; hematopoietic system; kidney; and mesoderm. Human ortholog(s) of this gene implicated in ovarian cancer and pancreatic cancer. Orthologous to human CLDN4 (claudin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb214 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zko630b | Allele with one insertion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cldng | China Zebrafish Resource Center (CZRC) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|---|
| UniProtKB:Q9YH90 | InterPro | 209 | |||
| UniProtKB:B2GPD3 | InterPro | 209 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-8H3 | ZFIN Curated Data | |
| Encodes | EST | cb214 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:136312 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152655 | Strausberg et al., 2002 | |
| Encodes | cDNA | MGC:158518 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:55699 | ZFIN Curated Data | |
| Has Artifact | cDNA | MGC:191477 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_180965 (1) | 1070 nt | ||
| Genomic | GenBank:CR762462 (1) | 186636 nt | ||
| Polypeptide | UniProtKB:B2GPD3 (1) | 209 aa |
No data available
- Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380
- Solis, C.J., Hamilton, M.K., Caruffo, M., Garcia-Lopez, J.P., Navarrete, P., Guillemin, K., Feijoo, C.G. (2020) Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Frontiers in immunology. 11:1330
- Winata, C.L., Łapiński, M., Pryszcz, L., Vaz, C., Bin Ismail, M.H., Nama, S., Hajan, H.S., Lee, S.G.P., Korzh, V., Sampath, P., Tanavde, V., Mathavan, S. (2017) Cytoplasmic polyadenylation-mediated translational control of maternal mRNAs directs maternal to zygotic transition. Development (Cambridge, England). 145(1)
- Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W., Yin, Z. (2016) The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models. Scientific Reports. 6:18597
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhang, P., He, Q., Chen, D., Liu, W., Wang, L., Zhang, C., Ma, D., Li, W., Liu, B., Liu, F. (2015) G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Cell Research. 25:1093-107
- Xu, T., Zhao, J., Hu, P., Dong, Z., Li, J., Zhang, H., Yin, D., Zhao, Q. (2014) Pentachlorophenol exposure causes Warburg-like effects in zebrafish embryos at gastrulation stage. Toxicology and applied pharmacology. 277:183-91
- Baltzegar, D.A., Reading, B.J., Brune, E.S., and Borski, R.J. (2013) Phylogenetic revision of the claudin gene family. Marine genomics. 11:17-26
- Aanes, H., Winata, C.L., Lin, C.H., Chen, J.P., Srinivasan, K.G., Lee, S.G., Lim, A.Y., Hajan, H.S., Collas, P., Bourque, G., Gong, Z., Korzh, V., Aleström, P., and Mathavan, S. (2011) Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome research. 21(8):1328-38
- Clelland, E.S., and Kelly, S.P. (2011) Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles. General and comparative endocrinology. 171(2):211-217
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