Gene

dvl3a

ID
ZDB-GENE-010319-1
Name
dishevelled segment polarity protein 3a
Symbol
dvl3a Nomenclature History
Previous Names
  • dvl3
  • wu:fb75f04
  • wu:fi22h02
  • wu:fp61b09
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have frizzled binding activity. Involved in canonical Wnt signaling pathway; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Localizes to cell cortex and spindle. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3. Orthologous to human DVL3 (dishevelled segment polarity protein 3).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Xing et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dvl3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant Robinow syndrome 3 Alliance Robinow syndrome, autosomal dominant 3 616894
Associated With dvl3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000591 DEP domain
Domain IPR001158 DIX domain
Domain IPR001478 PDZ domain
Domain IPR003351 Dishevelled protein domain
Domain IPR024580 Dishevelled C-terminal
Family IPR008339 Dishevelled family
Family IPR008342 Dishevelled-3
Family IPR015506 Dishevelled-related protein
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Homologous_superfamily IPR038207 DIX domain superfamily
Domain Details Per Protein
Protein Length DEP domain Dishevelled-3 Dishevelled C-terminal Dishevelled family Dishevelled protein domain Dishevelled-related protein DIX domain DIX domain superfamily PDZ domain PDZ superfamily Ubiquitin-like domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q9DGC7 676
UniProtKB:B8JMI2 676
UniProtKB:Q4KM11 676
UniProtKB:Q7ZU58 676
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations