Gene
or30bt2
- ID
- ZDB-GENE-010308-8
- Name
- odorant receptor family 30, subfamily BT, member 2
- Symbol
- or30bt2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in olfactory rosette. Orthologous to human OR2A12 (olfactory receptor family 2 subfamily A member 12) and OR2A5 (olfactory receptor family 2 subfamily A member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Sato et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22677 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Olfactory G-protein coupled receptor 1 | Olfactory receptor |
|---|---|---|---|---|---|---|
| UniProtKB:Q2PRC0 | InterPro | 314 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
or103-2-201
(1)
|
Ensembl | 2,155 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-133D24 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001039623 (1) | |||
| Genomic | GenBank:AL845428 (1) | 157787 nt | ||
| Polypeptide | UniProtKB:Q2PRC0 (1) | 314 aa |
No data available
- Behrens, M., Di Pizio, A., Redel, U., Meyerhof, W., Korsching, S.I. (2020) At the root of T2R gene evolution: Recognition profiles of coelacanth and zebrafish bitter receptors. Genome biology and evolution. 13(1)
- Olender, T., Jones, T.E.M., Bruford, E., Lancet, D. (2020) A unified nomenclature for vertebrate olfactory receptors. BMC Evolutionary Biology. 20:42
- Shao, X., Lakhina, V., Dang, P., Cheng, R.P., Marcaccio, C.L., Raper, J.A. (2017) Olfactory sensory axons target specific protoglomeruli in the olfactory bulb of zebrafish. Neural Development. 12:18
- Saraiva, L.R., Ahuja, G., Ivandic, I., Syed, A.S., Marioni, J.C., Korsching, S.I., Logan, D.W. (2015) Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Scientific Reports. 5:11487
- Ferreira, T., Wilson, S.R., Choi, Y.G., Risso, D., Dudoit, S., Speed, T.P., Ngai, J. (2014) Silencing of Odorant Receptor Genes by G Protein βγ Signaling Ensures the Expression of One Odorant Receptor per Olfactory Sensory Neuron. Neuron. 81(4):847-59
- Niimura, Y. (2009) On the Origin and Evolution of Vertebrate Olfactory Receptor Genes: Comparative Genome Analysis Among 23 Chordate Species. Genome biology and evolution. 1:34-44
- Sato, Y., Miyasaka, N., and Yoshihara, Y. (2007) Hierarchical regulation of odorant receptor gene choice and subsequent axonal projection of olfactory sensory neurons in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(7):1606-1615
- Alioto, T.S., and Ngai, J. (2005) The odorant receptor repertoire of teleost fish. BMC Genomics. 6:173
- Niimura, Y., and Nei, M. (2005) Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods. Proceedings of the National Academy of Sciences of the United States of America. 102(17):6039-6044
- Kratz, E., Dugas, J.C., and Ngai, J. (2002) Odorant receptor gene regulation: implications from genomic organization. Trends in genetics : TIG. 18(1):29-34
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