Gene
or42e3
- ID
- ZDB-GENE-010308-19
- Name
- odorant receptor, family 42, subfamily E, member 3
- Symbol
- or42e3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be active in membrane. Is expressed in olfactory rosette. Orthologous to several human genes including OR10J1 (olfactory receptor family 10 subfamily J member 1); OR10K1 (olfactory receptor family 10 subfamily K member 1); and OR10K2 (olfactory receptor family 10 subfamily K member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Sato et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11838 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13698 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15058 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35922 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein Coupled Receptor 1 Superfamily Member | G protein-coupled receptor, rhodopsin-like | Olfactory receptor |
|---|---|---|---|---|---|---|
| UniProtKB:F1R1K9 | InterPro | |||||
| UniProtKB:Q2PRD2 | InterPro | 326 | ||||
| UniProtKB:A0A8M2B4K9 | InterPro | 342 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
or111-2-201
(1)
|
Ensembl | 1,697 nt | ||
| mRNA |
or111-2-202
(1)
|
Ensembl | 897 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-133D24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193502 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193514 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128772 (1) | 1300 nt | ||
| Genomic | GenBank:AL845428 (1) | 157787 nt | ||
| Polypeptide | UniProtKB:A0A8M2B4K9 (1) | 342 aa |
No data available
- Olender, T., Jones, T.E.M., Bruford, E., Lancet, D. (2020) A unified nomenclature for vertebrate olfactory receptors. BMC Evolutionary Biology. 20:42
- Saraiva, L.R., Ahuja, G., Ivandic, I., Syed, A.S., Marioni, J.C., Korsching, S.I., Logan, D.W. (2015) Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Scientific Reports. 5:11487
- Ng, Y.K., Wu, W., and Zhang, L. (2009) Positive correlation between gene coexpression and positional clustering in the zebrafish genome. BMC Genomics. 10:42
- Niimura, Y. (2009) On the Origin and Evolution of Vertebrate Olfactory Receptor Genes: Comparative Genome Analysis Among 23 Chordate Species. Genome biology and evolution. 1:34-44
- Sato, Y., Miyasaka, N., and Yoshihara, Y. (2007) Hierarchical regulation of odorant receptor gene choice and subsequent axonal projection of olfactory sensory neurons in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(7):1606-1615
- Alioto, T.S., and Ngai, J. (2005) The odorant receptor repertoire of teleost fish. BMC Genomics. 6:173
- Niimura, Y., and Nei, M. (2005) Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods. Proceedings of the National Academy of Sciences of the United States of America. 102(17):6039-6044
- Kratz, E., Dugas, J.C., and Ngai, J. (2002) Odorant receptor gene regulation: implications from genomic organization. Trends in genetics : TIG. 18(1):29-34
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
- Dugas, J.C. and Ngai, J. (2001) Analysis and characterization of an odorant receptor gene cluster in the zebrafish genome. Genomics. 71(1):53-65
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