ZFIN is now using GRCz12tu for Genomic Data
Gene

slit3

ID
ZDB-GENE-010306-4
Name
slit homolog 3 (Drosophila)
Symbol
slit3 Nomenclature History
Previous Names
  • zgc:111911
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Predicted to enable Roundabout binding activity and heparin binding activity. Acts upstream of or within central nervous system projection neuron axonogenesis and negative regulation of axon extension. Predicted to be located in extracellular region. Is expressed in several structures, including axial mesoderm; fin; nervous system; pectoral fin bud; and presumptive mesoderm. Orthologous to human SLIT3 (slit guidance ligand 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slit3 Human Ortholog
No data available
Associated With slit3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000372 Leucine-rich repeat N-terminal domain
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR006207 Cystine knot, C-terminal
Family IPR051355 Notch and Slit guidance protein
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Domain Details Per Protein
Protein Additional Resources Length Concanavalin A-like lectin/glucanase domain superfamily Cysteine-rich flanking region, C-terminal Cystine knot, C-terminal EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Laminin G domain Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat N-terminal domain Leucine-rich repeat, typical subtype Notch and Slit guidance protein
UniProtKB:A0A8M3ARY3 InterPro 1322
UniProtKB:F1RCV3 InterPro 1516
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA slit3-202 (1)
Ensembl
Ensembl 6,146 nt
ZFIN BLAST
ncRNA slit3-002 (1)
Ensembl
Ensembl 1,244 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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