Gene

slit2

ID

ZDB-GENE-010306-3

Name

slit homolog 2 (Drosophila)

Symbol

slit2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have Roundabout binding activity and heparin binding activity. Involved in endocardial progenitor cell migration to the midline involved in heart field formation; generation of neurons; and morphogenesis of a branching structure. Predicted to localize to extracellular region. Is expressed in several structures, including axial mesoderm; forebrain neural tube; hypochord; nervous system; and neural plate. Orthologous to human SLIT2 (slit guidance ligand 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 19 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slit2 Human Ortholog

No data available

Associated With slit2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000372	Leucine-rich repeat N-terminal domain
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR003645	Follistatin-like, N-terminal
Domain	IPR006207	Cystine knot, C-terminal
Family	IPR051355	Notch and Slit guidance protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	Cysteine-rich flanking region, C-terminal	Cystine knot, C-terminal	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Follistatin-like, N-terminal	Growth factor receptor cysteine-rich domain superfamily	Laminin G domain	Leucine-rich repeat	Leucine-rich repeat domain superfamily	Leucine-rich repeat N-terminal domain	Leucine-rich repeat, typical subtype	Notch and Slit guidance protein
UniProtKB:A0A8M9PWQ2 InterPro	1527
UniProtKB:A0A8M9QD73 InterPro	1520
UniProtKB:A0A8M9Q7S3 InterPro	1544
UniProtKB:A0A8M9Q2G6 InterPro	1540
UniProtKB:A0A8M9Q7S7 InterPro	1533
UniProtKB:A0A8M9PWQ6 InterPro	1426
UniProtKB:A0A8M9PJ94 InterPro	1543
UniProtKB:A0A8M9Q7S9 InterPro	1516
UniProtKB:A0A8M9Q2G1 InterPro	1551
UniProtKB:A0A8M9QD69 InterPro	1536
UniProtKB:A0A8M9Q2H0 InterPro	1524
UniProtKB:Q9DE36 InterPro	1512
UniProtKB:A0A8M9PJA3 InterPro	1514
UniProtKB:A0A8M9QD64 InterPro	1547
UniProtKB:A0A8M9PWP8 InterPro	1542
UniProtKB:A0A8M9PJA0 InterPro	1532

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	slit2-201 (1) Ensembl	Ensembl	7,426 nt	Select Tool
mRNA	slit2-202 (1) Ensembl	Ensembl	8,663 nt	Select Tool ZFIN BLAST
mRNA	slit2-203 (1) Ensembl	Ensembl	8,553 nt	Select Tool ZFIN BLAST
mRNA	slit2-204 (1) Ensembl	Ensembl	8,690 nt	Select Tool ZFIN BLAST
mRNA	slit2-205 (1) Ensembl	Ensembl	8,649 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations