Gene
slit2
- ID
- ZDB-GENE-010306-3
- Name
- slit homolog 2 (Drosophila)
- Symbol
- slit2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have Roundabout binding activity and heparin binding activity. Involved in endocardial progenitor cell migration to the midline involved in heart field formation; generation of neurons; and morphogenesis of a branching structure. Predicted to localize to extracellular region. Is expressed in several structures, including axial mesoderm; forebrain neural tube; hypochord; nervous system; and neural plate. Orthologous to human SLIT2 (slit guidance ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR003645 | Follistatin-like, N-terminal |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Family | IPR051355 | Notch and Slit guidance protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Length | Concanavalin A-like lectin/glucanase domain superfamily | Cysteine-rich flanking region, C-terminal | Cystine knot, C-terminal | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Follistatin-like, N-terminal | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat N-terminal domain | Leucine-rich repeat, typical subtype | Notch and Slit guidance protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PWQ2
|
1527 | ||||||||||||||||
|
UniProtKB:A0A8M9QD73
|
1520 | ||||||||||||||||
|
UniProtKB:A0A8M9Q7S3
|
1544 | ||||||||||||||||
|
UniProtKB:A0A8M9Q2G6
|
1540 | ||||||||||||||||
|
UniProtKB:A0A8M9Q7S7
|
1533 | ||||||||||||||||
|
UniProtKB:A0A8M9PWQ6
|
1426 | ||||||||||||||||
|
UniProtKB:A0A8M9PJ94
|
1543 | ||||||||||||||||
|
UniProtKB:A0A8M9Q7S9
|
1516 | ||||||||||||||||
|
UniProtKB:A0A8M9Q2G1
|
1551 | ||||||||||||||||
|
UniProtKB:A0A8M9QD69
|
1536 | ||||||||||||||||
|
UniProtKB:A0A8M9Q2H0
|
1524 | ||||||||||||||||
|
UniProtKB:Q9DE36
|
1512 | ||||||||||||||||
|
UniProtKB:A0A8M9PJA3
|
1514 | ||||||||||||||||
|
UniProtKB:A0A8M9QD64
|
1547 | ||||||||||||||||
|
UniProtKB:A0A8M9PWP8
|
1542 | ||||||||||||||||
|
UniProtKB:A0A8M9PJA0
|
1532 |
Interactions and Pathways
No data available
Plasmids
No data available