Gene

mapk8b

ID

ZDB-GENE-010202-1

Name

mitogen-activated protein kinase 8b

Symbol

mapk8b Nomenclature History

Previous Names

jnk1 (1)
jnk1b (1)
JNK (1)
mapk8
jnk1a-1 (1)
zgc:112379

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable JUN kinase activity. Involved in JNK cascade and determination of dorsal identity. Predicted to be located in synapse. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; gut; head; pectoral fin; and pericardial region. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:112379 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mapk8b Human Ortholog

No data available

Associated With mapk8b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Conserved_site	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
Domain	IPR000719	Protein kinase domain
Family	IPR008351	Mitogen-activated protein (MAP) kinase, JNK
Family	IPR050117	Mitogen-activated protein kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Mitogen-activated protein kinase	Mitogen-activated protein (MAP) kinase, conserved site	Mitogen-activated protein (MAP) kinase, JNK	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:E9QB50 InterPro
UniProtKB:E9QJ67 InterPro
UniProtKB:F1RCB7 InterPro
UniProtKB:Q9DGD9 InterPro	384
UniProtKB:A0A8M6Z1Z5 InterPro	428

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mapk8b-201 (1) Ensembl	Ensembl	2,059 nt	Select Tool ZFIN BLAST
mRNA	mapk8b-202 (1) Ensembl	Ensembl	844 nt	Select Tool ZFIN BLAST
mRNA	mapk8b-203 (1) Ensembl	Ensembl	1,287 nt	Select Tool ZFIN BLAST
mRNA	mapk8b-204 (1) Ensembl	Ensembl	1,029 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations