Gene

dcn

ID

ZDB-GENE-010102-1

Name

decorin

Symbol

dcn Nomenclature History

Previous Names

DC (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have collagen binding activity and extracellular matrix structural constituent conferring compression resistance. Involved in cartilage development; chondroitin sulfate proteoglycan metabolic process; and convergent extension involved in axis elongation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and malignant glioma. Is expressed in several structures, including cranial cartilage; epidermis; nervous system; pericardial region; and periderm. Orthologous to human DCN (decorin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56723 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Zoeller et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dcn Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital stromal corneal dystrophy	Alliance	Corneal dystrophy, congenital stromal	610048

Associated With dcn Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000372	Leucine-rich repeat N-terminal domain
Family	IPR016352	Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
Family	IPR050333	Small Leucine-Rich Proteoglycans
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype