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ZIRC
ZFIN ID: ZDB-GENE-001229-2
Gene Name: aminolevulinate, delta-, synthase 1
Gene Symbol: alas1    Nomenclature History

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Previous Names: ALAS-N, unm_sm350, wu:fb58d01, wu:fi12g09, wu:fq33a02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have 5-aminolevulinate synthase activity and pyridoxal phosphate binding activity. Predicted to be involved in protoporphyrinogen IX biosynthetic process. Predicted to localize to the mitochondrial matrix. Is expressed in several structures, including EVL; digestive system; periderm; polster; and pronephros. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1).
Genome Resources: Alliance (1),  Gene:64608 (1),  Ensembl(GRCz11):ENSDARG00000021059 (2)
GENE EXPRESSION
All Expression Data: 13 figures from 3 publications
Directly Submitted Expression Data: 7 figures (11 images) from Thisse et al., 2004 [MGC:63935]
  4 figures (16 images) from Rauch et al., 2003 [fq33a02]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21822 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sm350 Point Mutation Donor Splice Site of Intron 7 Splice Site ENU
    szy1 Small Deletion Exon 7 Frameshift CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-alas1 1
    DISEASE ASSOCIATED WITH alas1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH alas1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neutrophil differentiation (more)
    Cellular Component mitochondrial matrix (more)
    Molecular Function 5-aminolevulinate synthase activity (more)
    GO Terms (all 13)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alas1-201 (1)    Ensembl 2030
    alas1-202 (1)    Ensembl 739
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alas1 No data available
    MARKER RELATIONSHIPS
    alas1 Contains: [SNP] rs3728336 (1), rs3728337 (1), rs3728338 (1)
    alas1 Encodes: [EST] fb58d01 (1), fi12g09 (1), fq33a02 (1) (order this)
    [cDNA] MGC:63935 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201287 (1) 2186 bp
    Polypeptide UniProtKB:F1RB22 (1) 621 aa
    Sequence Clusters UniGene:4829 (1)
    Sequence Information (all 17)
    ORTHOLOGY for alas1 ( Chr: 11 )
    CITATIONS (29)