Gene

alas1

ID

ZDB-GENE-001229-2

Name

aminolevulinate, delta-, synthase 1

Symbol

alas1 Nomenclature History

Previous Names

ALAS-N
unm_sm350
wu:fb58d01
wu:fi12g09
wu:fq33a02

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable 5-aminolevulinate synthase activity. Acts upstream of or within neutrophil differentiation. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including EVL; digestive system; periderm; polster; and pronephros. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63935 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alas1 Human Ortholog

No data available

Associated With alas1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR001917	Aminotransferase, class-II, pyridoxal-phosphate binding site
Domain	IPR004839	Aminotransferase, class I/classII, large domain
Domain	IPR010961	Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
Domain	IPR015118	5-aminolevulinate synthase presequence
Family	IPR050087	8-amino-7-oxononanoate synthase class-II
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase