Gene
alas1
- ID
- ZDB-GENE-001229-2
- Name
- aminolevulinate, delta-, synthase 1
- Symbol
- alas1 Nomenclature History
- Previous Names
-
- ALAS-N
- unm_sm350
- wu:fb58d01
- wu:fi12g09
- wu:fq33a02
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have 5-aminolevulinate synthase activity. Involved in neutrophil differentiation. Predicted to localize to mitochondrion. Is expressed in several structures, including EVL; digestive system; periderm; polster; and pronephros. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 14 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63935 (11 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR001917 | Aminotransferase, class-II, pyridoxal-phosphate binding site |
Domain | IPR004839 | Aminotransferase, class I/classII, large domain |
Domain | IPR010961 | Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase |
Domain | IPR015118 | 5-aminolevulinate synthase presequence |
Family | IPR050087 | 8-amino-7-oxononanoate synthase class-II |
Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
Protein | Length | 5-aminolevulinate synthase presequence | 8-amino-7-oxononanoate synthase class-II | Aminotransferase, class I/classII, large domain | Aminotransferase, class-II, pyridoxal-phosphate binding site | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain | Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q7T2F0
|
613 |
Interactions and Pathways
No data available
Plasmids
No data available