Gene
pcxb
- ID
- ZDB-GENE-000831-1
- Name
- pyruvate carboxylase b
- Symbol
- pcxb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate carboxylase activity. Acts upstream of or within response to cadmium ion. Predicted to be active in cytoplasm. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sandoval et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pyruvate carboxylase deficiency disease | Alliance | Pyruvate carboxylase deficiency | 266150 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001882 | Biotin-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR000891 | Pyruvate carboxyltransferase |
| Domain | IPR003379 | Carboxylase, conserved domain |
| Domain | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
| Domain | IPR005481 | Biotin carboxylase-like, N-terminal domain |
| Domain | IPR005482 | Biotin carboxylase, C-terminal |
| Domain | IPR011761 | ATP-grasp fold |
| Domain | IPR011764 | Biotin carboxylation domain |
| Family | IPR005930 | Pyruvate carboxylase |
| Homologous_superfamily | IPR011053 | Single hybrid motif |
| Homologous_superfamily | IPR011054 | Rudiment single hybrid motif |
| Homologous_superfamily | IPR013785 | Aldolase-type TIM barrel |
| Homologous_superfamily | IPR013815 | ATP-grasp fold, subdomain 1 |
| Homologous_superfamily | IPR016185 | Pre-ATP-grasp domain superfamily |
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | ATP-grasp fold | ATP-grasp fold, subdomain 1 | Biotin-binding site | Biotin carboxylase, C-terminal | Biotin carboxylase-like, N-terminal domain | Biotin carboxylation domain | Biotin/lipoyl attachment | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | Carboxylase, conserved domain | Pre-ATP-grasp domain superfamily | Pyruvate carboxylase | Pyruvate carboxyltransferase | Rudiment single hybrid motif | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QYZ6
|
1181 |
Interactions and Pathways
No data available
Plasmids
No data available