Gene

pcxb

ID
ZDB-GENE-000831-1
Name
pyruvate carboxylase b
Symbol
pcxb Nomenclature History
Previous Names
  • pc
  • pyc (1)
  • PYCb (1)
  • wu:fb82g08
  • wu:fj85g01 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have pyruvate carboxylase activity. Involved in response to cadmium ion. Predicted to localize to cytoplasm. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Sandoval et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pcxb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pyruvate carboxylase deficiency disease Alliance Pyruvate carboxylase deficiency 266150
Associated With pcxb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR001882 Biotin-binding site
Domain IPR000089 Biotin/lipoyl attachment
Domain IPR000891 Pyruvate carboxyltransferase
Domain IPR003379 Carboxylase, conserved domain
Domain IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
Domain IPR005481 Biotin carboxylase-like, N-terminal domain
Domain IPR005482 Biotin carboxylase, C-terminal
Domain IPR011761 ATP-grasp fold
Domain IPR011764 Biotin carboxylation domain
Family IPR005930 Pyruvate carboxylase
Homologous_superfamily IPR011053 Single hybrid motif
Homologous_superfamily IPR011054 Rudiment single hybrid motif
Homologous_superfamily IPR013785 Aldolase-type TIM barrel
Homologous_superfamily IPR016185 Pre-ATP-grasp domain superfamily
Domain Details Per Protein
Protein Length Aldolase-type TIM barrel ATP-grasp fold Biotin-binding site Biotin carboxylase, C-terminal Biotin carboxylase-like, N-terminal domain Biotin carboxylation domain Biotin/lipoyl attachment Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain Carboxylase, conserved domain Pre-ATP-grasp domain superfamily Pyruvate carboxylase Pyruvate carboxyltransferase Rudiment single hybrid motif Single hybrid motif
UniProtKB:B3DGZ9 1181
UniProtKB:Q58EN6 140
UniProtKB:F1QYZ6 1181
UniProtKB:Q7ZZ22 723
UniProtKB:B0S5R6 472
UniProtKB:Q9DDT1 1180
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations