Gene
hoxa3a
- ID
- ZDB-GENE-000823-3
- Name
- homeobox A3a
- Symbol
- hoxa3a Nomenclature History
- Previous Names
-
- hoxa3
- cb332 (1)
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; embryonic skeletal system morphogenesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; hindbrain; hindbrain neural keel; hindbrain neural plate; and pharyngeal arch. Orthologous to human HOXA3 (homeobox A3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb332 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| mn0040Gt | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-hoxa3a | N/A | Hogan et al., 2004 |
| MO2-hoxa3a | N/A | Hogan et al., 2004 |
| MO3-hoxa3a | N/A | Chen et al., 2010 |
| MO4-hoxa3a | N/A | Chen et al., 2010 |
| MO5-hoxa3a | N/A | Ma et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Domain of unknown function DUF4074 | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein, antennapedia type, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0N4SUA4 | InterPro | |||||||
| UniProtKB:A0A0N4SU55 | InterPro | |||||||
| UniProtKB:A0A0N4STW5 | InterPro | |||||||
| UniProtKB:Q8AWZ2 | InterPro | 410 | ||||||
| UniProtKB:A0AB32T9S9 | InterPro | 410 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxa3a-202
(1)
|
Ensembl | 492 nt | ||
| mRNA |
hoxa3a-203
(1)
|
Ensembl | 2,200 nt | ||
| mRNA |
hoxa3a-204
(1)
|
Ensembl | 358 nt | ||
| mRNA |
hoxa3a-205
(1)
|
Ensembl | 816 nt | ||
| mRNA |
hoxa3a-207
(1)
|
Ensembl | 405 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(5xUAS-Cca.Actb:HA-hoxa3a) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-25E11 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-227P06 | ZFIN Curated Data | |
| Encodes | EST | cb332 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:91782 | ZFIN Curated Data | |
| Has Artifact | EST | fa10d03 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131534 (1) | 2180 nt | ||
| Genomic | GenBank:CR382300 (1) | 202006 nt | ||
| Polypeptide | UniProtKB:A0AB32T9S9 (1) | 410 aa |
- Xue, S., Ly, T.T.N., Vijayakar, R.S., Chen, J., Ng, J., Mathuru, A.S., Magdinier, F., Reversade, B. (2022) HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring. Nature communications. 13:3583
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- González-Rojo, S., Fernández-Díez, C., Lombó, M., Herráez, M.P. (2018) Distribution of DNA damage in the sperm nucleus: A study of zebrafish as a model of histone-packaged chromatin. Theriogenology. 122:109-115
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J. (2018) Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development. Mechanisms of Development. 150:28-41
- Wang, J., Fei, F., Berberoglu, M.A., Sun, S., Wang, L., Dong, Z., Wang, X. (2018) Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis. Journal of molecular cell biology. 10(6):586-588
- Nakayama, Y., Inomata, C., Yuikawa, T., Tsuda, S., Yamasu, K. (2017) Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 involvement in neurogenesis. Developmental Biology. 430(1):237-248
- Ma, L.H., Grove, C.L., Baker, R. (2014) Development of oculomotor circuitry independent of hox3 genes. Nature communications. 5:4221
- van der Velden, Y.U., Wang, L., Querol Cano, L., and Haramis, A.P. (2013) The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development. PLoS One. 8(9):e73997
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