ZFIN ID: ZDB-GENE-000629-2
Gene Name: nerve growth factor b (beta polypeptide)
Gene Symbol: ngfb    Nomenclature History

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Previous Names: NGF, ngf, ngfb (1), ns:zft386, xx:zft386, zgc:109730

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; nervous system development; and positive regulation of peptidyl-serine phosphorylation. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including alar plate midbrain region; head mesenchyme; nervous system; periderm; and segmental plate. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).
Genome Resources: Alliance (1),  Gene:58133 (1),  Ensembl(GRCz11):ENSDARG00000014050 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ngfb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 5 Alliance Neuropathy, hereditary sensory and autonomic, type V 608654
DISEASE ASSOCIATED WITH ngfb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process memory (more)
Cellular Component extracellular region (more)
Molecular Function growth factor activity (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ngfb-201 (1)    Ensembl 1301
ngfb-202 (1)    Ensembl 1187
ngfb-203 (1)    Ensembl 1057
ngfb-204 (1)    Ensembl 1039
ngfb-205 (1)    Ensembl 773
ngfb-206 (1)    Ensembl 1291
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ngfb No data available
MARKER RELATIONSHIPS
ngfb Contained in: [BAC] CH211-105J21 (1), DKEY-183K8 (1) (order this)
ngfb Encodes: [EST] eu513 (1), zft386
[cDNA] MGC:109730 (1), MGC:192168 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_199210 (1) 1291 nt
Genomic GenBank:BX005150 (1) 167946 nt
Select Tool
Polypeptide UniProtKB:A0A0B5JS44 (1) 194 aa
Sequence Information (all 41)
ORTHOLOGY for ngfb ( Chr: 6 )
CITATIONS (42)