Gene

ngfb

ID
ZDB-GENE-000629-2
Name
nerve growth factor b (beta polypeptide)
Symbol
ngfb Nomenclature History
Previous Names
  • NGF
  • ngf
  • ngfb (1)
  • ns:zft386
  • xx:zft386
  • zgc:109730
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; nervous system development; and positive regulation of peptidyl-serine phosphorylation. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including alar plate midbrain region; head mesenchyme; nervous system; periderm; and segmental plate. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor).
Genome Resources
Note
None
Expression
All Expression Data
20 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ngfb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 5 Alliance Neuropathy, hereditary sensory and autonomic, type V 608654
Associated With ngfb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019846 Nerve growth factor conserved site
Domain IPR002072 Nerve growth factor-related
Family IPR020408 Nerve growth factor-like
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Nerve growth factor conserved site Nerve growth factor-like Nerve growth factor-related
UniProtKB:A0A0B5JS44 194
UniProtKB:Q6YBR5 194
UniProtKB:B2GR51 194
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations