ZFIN is now using GRCz12tu for Genomic Data
Gene
ngfb
- ID
- ZDB-GENE-000629-2
- Name
- nerve growth factor b (beta polypeptide)
- Symbol
- ngfb Nomenclature History
- Previous Names
-
- NGF
- ngf
- ngfb (1)
- ns:zft386
- xx:zft386
- zgc:109730
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of neuron apoptotic process; and nervous system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space and synaptic vesicle. Is expressed in several structures, including alar plate midbrain region; gonad; kidney; nervous system; and periderm. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and opiate dependence (multiple). Orthologous to human NGF (nerve growth factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109730 (16 images)
- eu513 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory and autonomic neuropathy type 5 | Alliance | Neuropathy, hereditary sensory and autonomic, type V | 608654 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Nerve growth factor conserved site | Nerve growth factor-like | Nerve growth factor-related |
|---|---|---|---|---|---|---|
| UniProtKB:Q6YBR5 | InterPro | 194 | ||||
| UniProtKB:A0A8M1PAS0 | InterPro | 224 | ||||
| UniProtKB:B2GR51 | InterPro | 194 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ngfb-201
(1)
|
Ensembl | 1,301 nt | ||
| mRNA |
ngfb-202
(1)
|
Ensembl | 1,187 nt | ||
| mRNA |
ngfb-203
(1)
|
Ensembl | 1,057 nt | ||
| mRNA |
ngfb-204
(1)
|
Ensembl | 1,039 nt | ||
| mRNA |
ngfb-205
(1)
|
Ensembl | 773 nt | ||
| mRNA |
ngfb-206
(1)
|
Ensembl | 1,291 nt | ||
| mRNA |
ngfb-207
(1)
|
Ensembl | 588 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers