Gene

ngfb

ID
ZDB-GENE-000629-2
Name
nerve growth factor b (beta polypeptide)
Symbol
ngfb Nomenclature History
Previous Names
  • NGF
  • ngf
  • ngfb (1)
  • ns:zft386
  • xx:zft386
  • zgc:109730
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have growth factor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of neuron apoptotic process; and nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal failure; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Is expressed in several structures, including alar plate midbrain region; head mesenchyme; nervous system; periderm; and segmental plate. Orthologous to human NGF (nerve growth factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
20 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ngfb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 5 Alliance Neuropathy, hereditary sensory and autonomic, type V 608654
Associated With ngfb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019846 Nerve growth factor conserved site
Domain IPR002072 Nerve growth factor-related
Family IPR020408 Nerve growth factor-like
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Nerve growth factor conserved site Nerve growth factor-like Nerve growth factor-related
UniProtKB:B2GR51 194
UniProtKB:A0A0B5JS44 194
UniProtKB:Q6YBR5 194
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations